{"items":[{"id":"lisinopril","name":"Lisinopril","kind":"drug","url":"https://interaction-checker.com/drugs/lisinopril","query":"lisinopril"},{"id":"ibuprofen","name":"Ibuprofen","kind":"drug","url":"https://interaction-checker.com/drugs/ibuprofen","query":"ibuprofen"}],"unresolved":[],"pairs":[{"a":{"id":"lisinopril","name":"Lisinopril","kind":"drug","url":"https://interaction-checker.com/drugs/lisinopril"},"b":{"id":"ibuprofen","name":"Ibuprofen","kind":"drug","url":"https://interaction-checker.com/drugs/ibuprofen"},"severity":"moderate","severityLabel":"Moderate","url":"https://interaction-checker.com/?d=lisinopril,ibuprofen","page":"https://interaction-checker.com/interactions/ibuprofen-and-lisinopril","evidence":[{"from":"ibuprofen","about":"lisinopril","section":"warnings_and_cautions","sectionLabel":"Warnings and precautions","severity":"moderate","quote":"Patients at greatest risk of this reaction are those with impaired renal function, dehydration, hypovolemia, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors or ARBs, and the elderly.","matchedTerm":"ace inhibitor","matchKind":"class","source":{"type":"fda_label","name":"Caldolor prescribing label (Cumberland Pharmaceuticals Inc.)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1eaa7790-f1a1-4f51-b10a-cbbaf033f684","effectiveDate":"2026-01-29"}},{"from":"ibuprofen","about":"lisinopril","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"moderate","quote":"In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.","matchedTerm":"ace inhibitor","matchKind":"class","source":{"type":"fda_label","name":"Caldolor prescribing label (Cumberland Pharmaceuticals Inc.)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1eaa7790-f1a1-4f51-b10a-cbbaf033f684","effectiveDate":"2026-01-29"}},{"from":"ibuprofen","about":"lisinopril","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"moderate","quote":"Intervention: During concomitant use of CALDOLOR and ACE-inhibitors, ARBs, or beta- blockers, monitor blood pressure to ensure that the desired blood pressure is obtained.","matchedTerm":"ace inhibitor","matchKind":"class","source":{"type":"fda_label","name":"Caldolor prescribing label (Cumberland Pharmaceuticals Inc.)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1eaa7790-f1a1-4f51-b10a-cbbaf033f684","effectiveDate":"2026-01-29"}},{"from":"ibuprofen","about":"lisinopril","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"moderate","quote":"During concomitant use of CALDOLOR and ACE-inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor for signs of worsening renal function [ see Warnings and Precautions ( 5.6 ) ].","matchedTerm":"ace inhibitor","matchKind":"class","source":{"type":"fda_label","name":"Caldolor prescribing label (Cumberland Pharmaceuticals Inc.)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1eaa7790-f1a1-4f51-b10a-cbbaf033f684","effectiveDate":"2026-01-29"}},{"from":"ibuprofen","about":"lisinopril","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"moderate","quote":"Intervention: During concomitant use of CALDOLOR with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects [ see Warnings and Precautions ( 5.6 ) ].","matchedTerm":"antihypertensive","matchKind":"class","source":{"type":"fda_label","name":"Caldolor prescribing label (Cumberland Pharmaceuticals Inc.)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1eaa7790-f1a1-4f51-b10a-cbbaf033f684","effectiveDate":"2026-01-29"}},{"from":"lisinopril","about":"ibuprofen","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"moderate","quote":"NSAIDS: Increased risk of renal impairment and loss of antihypertensive efficacy ( 7.3 )","matchedTerm":"nsaid","matchKind":"class","source":{"type":"fda_label","name":"Zestril prescribing label (Upsher-Smith Laboratories, LLC)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8","effectiveDate":"2025-01-02"}},{"from":"lisinopril","about":"ibuprofen","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"moderate","quote":"Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including lisinopril, may result in deterioration…","matchedTerm":"non steroidal anti inflammatory","matchKind":"class","source":{"type":"fda_label","name":"Zestril prescribing label (Upsher-Smith Laboratories, LLC)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8","effectiveDate":"2025-01-02"}},{"from":"lisinopril","about":"ibuprofen","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"moderate","quote":"Monitor renal function periodically in patients receiving lisinopril and NSAID therapy.","matchedTerm":"nsaid","matchKind":"class","source":{"type":"fda_label","name":"Zestril prescribing label (Upsher-Smith Laboratories, LLC)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8","effectiveDate":"2025-01-02"}},{"from":"lisinopril","about":"ibuprofen","section":"drug_interactions","sectionLabel":"Drug interactions","severity":"minor","quote":"The antihypertensive effect of ACE inhibitors, including lisinopril, may be attenuated by NSAIDs.","matchedTerm":"nsaid","matchKind":"class","source":{"type":"fda_label","name":"Zestril prescribing label (Upsher-Smith Laboratories, LLC)","url":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8","effectiveDate":"2025-01-02"}}]}],"summary":{"major":0,"moderate":1,"minor":0,"none":0,"unknown":0},"data":{"labelExportDate":"2026-09-03","generatedAt":"2026-09-08"},"disclaimer":"Not medical advice. Severity reflects the wording of FDA prescribing labels, not an individual's situation, and the absence of a documented interaction is not evidence of safety. Confirm with a pharmacist or prescriber.","attribution":{"text":"Data from Interaction Checker (https://interaction-checker.com), built on FDA prescribing labels via openFDA and DailyMed.","url":"https://interaction-checker.com","license":"FDA label text is public domain. The arrangement and grading are free to use with a link back."}}