Bosentan and Glyburide and metformin interaction
Bosentan and Glyburide and metformin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Bosentan (Tracleer) label · effective 2025-11-17
Use with Glyburide ( 4.3 ).
Use with Glyburide An increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with bosentan.
Therefore co-administration of glyburide and TRACLEER is contraindicated [see Drug Interactions (7.1) ] .
From the Glyburide and metformin (glyburide and metformin hydrochloride) label · effective 2026-06-10
Concomitant administration of bosentan [see Drug Interactions ( 7 ) ].
Bosentan Clinical Impact: Increased risk of liver enzyme elevations was observed.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.