Interaction Checker

Drug reference

1,042 of the most prescribed and most bought medicines in the United States: every interaction each FDA label documents, what the pills look like, and sourced facts. Look a drug up by generic name, brand, or class.

Try a brand like Lipitor, a class like statin, or plain words like blood thinner.

CommonIbuprofenLisinoprilSertralineTramadolAspirinWarfarinAtorvastatinMetforminAlprazolamOxycodone
By classstatin9SSRI8beta blocker19ACE inhibitor17ARB18NSAID30opioid31benzodiazepine14antibiotic74proton pump inhibitor8antihistamine25anticoagulant10antidiabetic38corticosteroid23CNS stimulant21calcium channel blocker15

A

B

C

D

E

F

  • FamciclovirFamvirantiviral
    4 moderate66 total
  • FamotidinePepcidH2 blocker
    12 major28 moderate60 total
  • FebuxostatUloricxanthine oxidase inhibitor
    10 major88 moderate136 total
  • FelbamateFelbatolanticonvulsant
    101 major132 moderate254 total
  • FelodipinePlendildihydropyridine calcium channel blocker
    18 major192 moderate270 total
  • FenofibrateTricor, Lipofenfibrate
    2 major66 moderate72 total
  • Fenofibric acidTrilipix, Fibricorfibrate
    2 major65 moderate72 total
  • FenoprofenNalfonNSAID
    50 major232 moderate298 total
  • FentanylDuragesic, Actiqopioid
    277 major141 moderate432 total
  • Ferric citrateAuryxiaphosphate binder
    38 major18 moderate60 total
  • FesoterodineToviazanticholinergic
    54 major155 moderate251 total
  • FexofenadineAllegraantihistamine
    9 major31 moderate82 total
  • FidaxomicinDificidmacrolide antibiotic
    8 major70 moderate88 total
  • FilgrastimNeupogen, Zarxio
    2 major2 moderate4 total
  • FinasteridePropecia, Proscar5-alpha reductase inhibitor
    8 major156 total
  • FingolimodGilenya, Tascensoimmunosuppressant
    43 major89 moderate180 total
  • Flavoxateanticholinergic
    14 major77 moderate105 total
  • FlecainideTambocorantiarrhythmic
    59 major91 moderate210 total
  • FlibanserinAddyiCNS depressant
    157 major162 moderate333 total
  • Floxuridineantimetabolite
    1 major1 total
  • FluconazoleDiflucanazole antifungal
    207 major236 moderate463 total
  • FlucytosineAncobonantifungal
    3 moderate12 total
  • FludarabineFludaraantimetabolite
    24 total
  • FludrocortisoneFlorinefcorticosteroid
    56 major268 moderate374 total
  • FlumazenilRomaziconbenzodiazepine
    112 major107 moderate254 total
  • Flunisolidecorticosteroid
    54 major185 moderate337 total
  • FluocinonideLidex, Vanoscorticosteroid
    29 major193 moderate309 total
  • FluorouracilAdrucil, Efudexantimetabolite
    6 major29 moderate45 total
  • FluoxetineProzac, SarafemSSRI
    121 major308 moderate490 total
  • FluphenazineProlixinantipsychotic
    95 major140 moderate251 total
  • FlurbiprofenAnsaidNSAID
    50 major197 moderate256 total
  • FlutamideEulexinandrogen
    3 major37 moderate40 total
  • FluticasoneFlonase, Floventcorticosteroid
    65 major196 moderate341 total
  • Fluticasone and salmeterolAdvair, Wixelacorticosteroid
    113 major260 moderate442 total
  • FluvastatinLescolstatin
    19 major51 moderate111 total
  • FluvoxamineLuvoxSSRI
    109 major248 moderate388 total
  • FollitropinGonal-f, Follistim AQ
    38 major22 moderate60 total
  • FomepizoleAntizol
    5 moderate5 total
  • FondaparinuxArixtraanticoagulant
    56 major123 moderate205 total
  • FormoterolPerforomist, Foradilbeta-adrenergic agonist
    81 major171 moderate271 total
  • FosamprenavirLexivaantiretroviral
    308 major204 moderate535 total
  • FosaprepitantEmend for Injection, FocinvezCYP3A4 inhibitor
    97 major158 moderate276 total
  • FoscarnetFoscavirantiviral
    80 major65 moderate149 total
  • FosfomycinMonurolantibiotic
    80 major37 moderate117 total
  • FosinoprilMonoprilACE inhibitor
    30 major160 moderate243 total
  • Fosinopril and hydrochlorothiazideACE inhibitor
    58 major274 moderate389 total
  • FosphenytoinCerebyx, Sesquientanticonvulsant
    141 major316 moderate492 total
  • FrovatriptanFrovatriptan
    87 major5 moderate98 total
  • FulvestrantFaslodexestrogen
    22 major111 moderate188 total
  • FurosemideLasix, Furoscixloop diuretic
    29 major310 moderate384 total

G

H

I

K

  • KetamineKetalar, SpravatoCNS depressant
    206 major67 moderate288 total
  • KetoconazoleNizoralazole antifungal
    313 major251 moderate583 total
  • KetoprofenNSAID
    46 major153 moderate247 total
  • KetorolacToradol, SprixNSAID
    83 major147 moderate315 total

L

M

  • MacitentanOpsumit
    77 major117 total
  • MaravirocSelzentryantiretroviral
    54 major36 moderate100 total
  • MargetuximabMargenza
    68 moderate68 total
  • MebendazoleEmverm, Vermox
    2 major4 total
  • MecamylamineVecamylantihypertensive
    16 major157 moderate193 total
  • MecaserminIncrelex
    1 major8 total
  • MeclizineAntivert, Bonineantihistamine
    80 major175 moderate312 total
  • MedroxyprogesteroneProvera, Depo-Proveraprogestin
    23 major134 moderate205 total
  • Mefenamic acidPonstelNSAID
    50 major201 moderate260 total
  • Mefloquineantimalarial
    6 major228 moderate250 total
  • MegestrolMegaceprogestin
    16 major106 moderate175 total
  • MeloxicamMobic, VivlodexNSAID
    50 major212 moderate271 total
  • MelphalanAlkeran, Evomela
    1 major2 moderate51 total
  • MemantineNamenda
    6 moderate15 total
  • Memantine and donepezilNamzariccholinesterase inhibitor
    1 major81 moderate197 total
  • Menthol and methyl salicylateBengay, Icy Hotsalicylate
    25 major48 moderate76 total
  • MeperidineDemerolopioid
    274 major99 moderate390 total
  • MepivacaineCarbocaine, Polocainelocal anesthetic
    40 major114 moderate156 total
  • MepolizumabNucala
    23 moderate23 total
  • MeprobamateCNS depressant
    62 major139 moderate208 total
  • MercaptopurinePurixanantimetabolite
    13 major81 moderate109 total
  • MeropenemMerremantibiotic
    4 major1 moderate31 total
  • MesalamineLialda, Asacolsalicylate
    25 major60 moderate89 total
  • MesnaMesnex
    2 major1 moderate5 total
  • MetaxaloneSkelaxin, Metaxallmuscle relaxant
    222 major36 moderate269 total
  • MetforminGlucophage, Glumetzabiguanide
    15 major110 moderate246 totalFacts
  • MethadoneDolophine, Methadoseopioid
    267 major166 moderate458 total
  • MethamphetamineDesoxynCNS stimulant
    123 major52 moderate222 total
  • MethazolamideNeptazanecarbonic anhydrase inhibitor
    44 major55 moderate109 total
  • MethenamineHiprex, Urexantibiotic
    4 moderate5 total
  • MethimazoleTapazoleantithyroid drug
    18 major99 moderate202 total
  • MethocarbamolRobaxinmuscle relaxant
    84 major139 moderate233 total
  • MethohexitalBrevitalbarbiturate
    107 major136 moderate307 total
  • MethotrexateTrexall, Otrexupimmunosuppressant
    52 major113 moderate184 total
  • MethscopolaminePamineanticholinergic
    14 major111 moderate139 total
  • MethsuximideCelontinanticonvulsant
    75 major128 moderate223 total
  • MethyldopaAldometantihypertensive
    17 major141 moderate244 total
  • Methylene blueProvayBlueMAO inhibitor
    122 major59 moderate204 total
  • MethylergonovineMethergineergot alkaloid
    54 major74 moderate146 total
  • MethylnaltrexoneRelistoropioid antagonist
    43 major2 moderate52 total
  • MethylphenidateRitalin, ConcertaCNS stimulant
    51 major153 moderate224 total
  • MethylprednisoloneMedrol, Solu-Medrolcorticosteroid
    30 major271 moderate386 total
  • MethyltestosteroneMethitest, Androidandrogen
    4 major57 moderate95 total
  • MetoclopramideReglan, Gimotidopamine antagonist
    146 major109 moderate262 total
  • MetolazoneZaroxolynthiazide diuretic
    103 major286 moderate423 total
  • MetoprololLopressor, Toprol-XLbeta blocker
    41 major193 moderate312 totalFacts
  • Metoprolol and hydrochlorothiazideLopressor HCT, Dutoprolbeta blocker
    44 major355 moderate460 total
  • MetronidazoleFlagylantibiotic
    8 major101 moderate121 total
  • MetyraponeMetopirone
    9 major25 moderate66 total
  • MetyrosineDemser
    22 major168 moderate190 total
  • Mexiletineantiarrhythmic
    37 major78 moderate263 total
  • MicafunginMycamineantifungal
    8 moderate51 total
  • MiconazoleMonistat, Micatinazole antifungal
    19 major82 moderate164 total
  • MidazolamVersed, Nayzilambenzodiazepine
    187 major73 moderate288 total
  • MidodrineProAmatine, Orvatenalpha-adrenergic agonist
    31 major49 moderate140 total
  • MifepristoneMifeprex, KorlymCYP3A4 inhibitor
    163 major233 moderate432 total
  • MiglitolGlysetantidiabetic
    4 major99 moderate120 total
  • MiglustatZavesca, Opfolda
    1 moderate1 total
  • MilnacipranSavellaSNRI
    95 major94 moderate193 total
  • MilrinonePDE3 inhibitor
    7 major56 total
  • MinocyclineMinocin, Solodyntetracycline antibiotic
    17 major27 moderate62 total
  • MinoxidilLoniten, Rogainevasodilator
    96 major73 moderate192 total
  • MirabegronMyrbetriqbeta-adrenergic agonist
    132 major223 moderate407 total
  • MirtazapineRemeronantidepressant
    184 major216 moderate418 total
  • MisoprostolCytotecprostaglandin analog
    40 major12 moderate56 total
  • MitapivatPyrukynd, AqvesmeCYP3A4 inducer
    143 major99 moderate258 total
  • MitotaneLysodrenCYP3A4 inducer
    132 major95 moderate245 total
  • Mitoxantrone
    2 major9 moderate34 total
  • ModafinilProvigilCNS stimulant
    121 major253 moderate414 total
  • MoexiprilUnivascACE inhibitor
    67 major159 moderate311 total
  • MometasoneNasonex, Eloconcorticosteroid
    29 major247 moderate353 total
  • MontelukastSingulairleukotriene receptor antagonist
    30 major26 moderate276 total
  • MorphineMS Contin, Kadianopioid
    230 major129 moderate376 total
  • MotixafortideAphexda
    59 moderate59 total
  • MoxifloxacinAvelox, Vigamoxfluoroquinolone
    47 major217 moderate266 total
  • MycophenolateCellCept, Myforticimmunosuppressant
    11 major136 moderate166 total

N

O

P

Q

R

  • RabeprazoleAciphexproton pump inhibitor
    13 major88 moderate108 total
  • RaloxifeneEvistaselective estrogen receptor modulator
    19 major14 moderate64 total
  • RaltegravirIsentressantiretroviral
    20 major16 moderate131 total
  • RamelteonRozeremsedative-hypnotic
    87 major179 moderate285 total
  • RamiprilAltaceACE inhibitor
    33 major142 moderate203 total
  • RanitidineZantacH2 blocker
    7 major38 moderate65 total
  • RanolazineRanexa, AspruzyoQT-prolonging drug
    150 major195 moderate371 total
  • RasagilineAzilectMAO inhibitor
    117 major98 moderate224 total
  • RemifentanilUltivaopioid
    238 major41 moderate317 total
  • RepaglinidePrandinmeglitinide
    35 major175 moderate391 total
  • RibavirinVirazoleantiviral
    24 major1 moderate29 total
  • RifabutinMycobutinantibiotic
    117 major138 moderate275 total
  • RifampinRifadin, Rimactaneantibiotic
    178 major306 moderate496 total
  • RifapentinePriftinantibiotic
    97 major368 moderate475 total
  • RifaximinXifaxanantibiotic
    31 moderate59 total
  • RilpivirineEdurantantiretroviral
    85 major124 moderate265 total
  • RiluzoleRilutek, Tiglutik
    33 moderate36 total
  • RimegepantNurtec
    74 major1 moderate75 total
  • RiociguatAdempasvasodilator
    29 major106 moderate173 total
  • RisedronateActonel, Atelviabisphosphonate
    25 major39 moderate112 total
  • RisperidoneRisperdal, Perserisantipsychotic
    115 major249 moderate385 total
  • RitlecitinibLitfuloJAK inhibitor
    50 major25 moderate116 total
  • RitonavirNorvirantiretroviral
    344 major243 moderate597 total
  • RituximabRituxan, Truximaimmunosuppressant
    13 major32 moderate140 total
  • RivaroxabanXareltoanticoagulant
    114 major106 moderate245 total
  • RivastigmineExeloncholinesterase inhibitor
    87 major33 moderate130 total
  • RizatriptanMaxalttriptan
    76 major20 moderate124 total
  • RocuroniumZemuronneuromuscular blocker
    12 major196 moderate219 total
  • RoflumilastDalirespPDE4 inhibitor
    53 major54 moderate108 total
  • RolapitantVarubiCYP2D6 inhibitor
    51 major41 moderate101 total
  • RomidepsinIstodax
    32 major34 moderate67 total
  • RopiniroleRequipdopamine agonist
    63 major127 moderate283 total
  • RopivacaineNaropinlocal anesthetic
    15 major156 moderate184 total
  • RosuvastatinCrestor, Ezallorstatin
    16 major61 moderate111 total
  • RufinamideBanzelanticonvulsant
    75 major156 moderate263 total
  • RuxolitinibJakafi, OpzeluraJAK inhibitor
    10 major65 moderate75 total

S

T

  • TacrolimusPrograf, Envarsusimmunosuppressant
    69 major264 moderate344 total
  • TadalafilCialis, AdcircaPDE5 inhibitor
    107 major85 moderate198 total
  • TafasitamabMonjuvi
    1 major1 total
  • TafenoquineKrintafel, Arakodaantimalarial
    12 major19 moderate34 total
  • TalazoparibTalzenna
    31 major31 total
  • TamoxifenSoltamox, Nolvadexselective estrogen receptor modulator
    68 major68 moderate155 total
  • TamsulosinFlomaxalpha blocker
    62 major40 moderate121 total
  • TapentadolNucyntaopioid
    231 major104 moderate353 total
  • TasimelteonHetliozsedative-hypnotic
    113 major71 moderate197 total
  • TelmisartanMicardisangiotensin II receptor blocker (ARB)
    24 major126 moderate169 total
  • Telmisartan and amlodipineTwynstaangiotensin II receptor blocker (ARB)
    32 major242 moderate357 total
  • Telmisartan and hydrochlorothiazideMicardis HCTangiotensin II receptor blocker (ARB)
    41 major278 moderate361 total
  • TelotristatXermelo
    6 moderate6 total
  • TemazepamRestorilbenzodiazepine
    129 major125 moderate266 total
  • TemozolomideTemodar
    9 major23 moderate32 total
  • TemsirolimusTorisel
    2 major212 moderate215 total
  • TenapanorIbsrela, Xphozah
    4 moderate4 total
  • TenecteplaseTNKase
    1 major22 moderate74 total
  • TenofovirViread, Vemlidyantiretroviral
    66 major25 moderate100 total
  • TerazosinHytrinalpha blocker
    12 major153 moderate188 total
  • TerbinafineLamisilantifungal
    18 major89 moderate243 total
  • TerbutalineBrethinebeta-adrenergic agonist
    60 major125 moderate206 total
  • TeriflunomideAubagioimmunosuppressant
    14 major101 moderate134 total
  • TeriparatideForteo, Bonsitythyroid hormone
    17 major89 moderate147 total
  • TesamorelinEgrifta
    23 moderate55 total
  • TestosteroneAndroGel, Testimandrogen
    4 major144 moderate153 total
  • TetrabenazineXenazineVMAT2 inhibitor
    154 major209 moderate372 total
  • TetracyclineSumycin, Achromycintetracycline antibiotic
    19 major28 moderate76 total
  • TheophyllineTheo-24, Elixophyllinmethylxanthine
    14 major271 moderate339 total
  • Thioridazineantipsychotic
    183 major121 moderate327 total
  • ThiotepaTepadina
    65 major3 moderate68 total
  • Thiothixeneantipsychotic
    90 major165 moderate272 total
  • TiagabineGabitrilanticonvulsant
    75 major144 moderate316 total
  • TicagrelorBrilintaantiplatelet agent
    142 major169 moderate329 total
  • TigecyclineTygaciltetracycline antibiotic
    8 major19 moderate61 total
  • TimololTimoptic, Betimolbeta blocker
    14 major166 moderate195 total
  • TinidazoleTindamaxantibiotic
    5 major125 moderate134 total
  • TioproninThiola, Venxxiva
    1 major1 total
  • TiotropiumSpirivaanticholinergic
    72 major147 moderate239 total
  • TirofibanAggrastatantiplatelet agent
    12 major47 moderate65 total
  • TirzepatideMounjaro, ZepboundGLP-1 receptor agonist
    17 major143 moderate184 total
  • TizanidineZanaflexmuscle relaxant
    143 major208 moderate392 total
  • TobramycinTobrex, Tobiaminoglycoside
    11 major53 moderate117 total
  • TocilizumabActemraimmunosuppressant
    33 major73 moderate144 total
  • TofacitinibXeljanzimmunosuppressant
    42 major113 moderate167 total
  • TolcaponeTasmar
    10 major75 moderate151 total
  • TolmetinTolectinNSAID
    44 major151 moderate268 total
  • TolterodineDetrolanticholinergic
    40 major138 moderate193 total
  • TolvaptanSamsca, Jynarque
    66 major56 moderate139 total
  • TopiramateTopamax, Trokendianticonvulsant
    155 major287 moderate462 total
  • TopotecanHycamtin
    30 major3 moderate34 total
  • ToremifeneFarestonselective estrogen receptor modulator
    87 major124 moderate223 total
  • TorsemideDemadex, Soaanzloop diuretic
    28 major297 moderate372 total
  • TrabectedinYondelis
    66 major66 total
  • TramadolUltram, ConZipopioid
    286 major130 moderate426 totalFacts
  • Tramadol and acetaminophenUltracetopioid
    290 major151 moderate461 total
  • TrandolaprilMavikACE inhibitor
    47 major190 moderate315 total
  • Tranexamic acidLysteda, Cyklokapronantifibrinolytic
    23 major26 total
  • TranylcypromineParnateMAO inhibitor
    231 major161 moderate399 total
  • TrastuzumabHerceptin, Ogivri
    4 major48 moderate75 total
  • TrazodoneDesyrel, Oleptroantidepressant
    171 major312 moderate492 totalFacts
  • TreprostinilRemodulin, Tyvasoprostaglandin analog
    3 major74 moderate103 total
  • TretinoinRetin-A, Renovaretinoid
    96 major9 moderate106 total
  • TriamcinoloneKenalog, Nasacortcorticosteroid
    30 major287 moderate397 total
  • TriamtereneDyreniumpotassium-sparing diuretic
    32 major294 moderate365 total
  • Triamterene and hydrochlorothiazideMaxzide, Dyazidepotassium-sparing diuretic
    47 major342 moderate421 total
  • TriazolamHalcionbenzodiazepine
    212 major52 moderate275 total
  • TrifluoperazineStelazineantipsychotic
    117 major175 moderate366 total
  • TrihexyphenidylArtaneanticholinergic
    38 major172 moderate237 total
  • TrilaciclibCosela
    1 major2 moderate8 total
  • TrimethobenzamideTigan
    26 major166 moderate192 total
  • TrimethoprimPrimsolantibiotic
    6 major38 moderate55 total
  • TrimipramineSurmontiltricyclic antidepressant
    130 major153 moderate343 total
  • TriptorelinTrelstar, Triptodur
    77 moderate77 total
  • TrospiumSancturaanticholinergic
    14 major135 moderate162 total

U

V

  • ValacyclovirValtrexantiviral
    1 major5 moderate7 total
  • ValbenazineIngrezzaVMAT2 inhibitor
    85 major162 moderate251 total
  • ValganciclovirValcyteantiviral
    2 major21 moderate23 total
  • Valproic acidDepakene, Stavzoranticonvulsant
    103 major181 moderate340 total
  • ValsartanDiovan, Prexxartanangiotensin II receptor blocker (ARB)
    20 major133 moderate171 total
  • Valsartan and hydrochlorothiazideDiovan HCTangiotensin II receptor blocker (ARB)
    46 major274 moderate362 total
  • VancomycinVancocin, Firvanqantibiotic
    4 major15 moderate21 total
  • VardenafilLevitra, StaxynPDE5 inhibitor
    56 major168 moderate249 total
  • VareniclineChantix, Tyrvaya
    1 major22 moderate23 total
  • VasopressinVasostrict
    2 major44 moderate47 total
  • Vecuroniumneuromuscular blocker
    6 major41 moderate71 total
  • VenlafaxineEffexorSNRI
    120 major260 moderate413 total
  • VepdegestrantVeppanu
    127 major134 total
  • VerapamilCalan, Verelancalcium channel blocker
    126 major311 moderate488 total
  • VericiguatVerquvovasodilator
    4 major9 moderate19 total
  • VibegronGemtesabeta-adrenergic agonist
    36 major111 moderate173 total
  • VigabatrinSabril, Vigadroneanticonvulsant
    76 major125 moderate221 total
  • VilazodoneViibrydSSRI
    98 major214 moderate335 total
  • ViloxazineQelbreenorepinephrine reuptake inhibitor
    28 major94 moderate156 total
  • VincristineVincasar PFS
    51 major31 moderate97 total
  • VinorelbineNavelbine
    44 moderate45 total
  • VoriconazoleVfendazole antifungal
    164 major320 moderate506 total
  • VortioxetineTrintellixantidepressant
    95 major189 moderate303 total

W

  • WarfarinCoumadin, Jantovenanticoagulant
    24 major321 moderate391 total

Z

  • ZafirlukastAccolateleukotriene receptor antagonist
    2 major88 moderate133 total
  • ZaleplonSonatasedative-hypnotic
    180 major79 moderate266 total
  • ZanamivirRelenzaantiviral
    20 moderate20 total
  • ZavegepantZavzpret
    4 major4 total
  • ZenocutuzumabBizengri
    55 moderate55 total
  • ZidovudineRetrovirantiretroviral
    37 major26 moderate70 total
  • ZileutonZyfloCYP1A2 inhibitor
    9 major45 moderate130 total
  • ZiprasidoneGeodonantipsychotic
    211 major239 moderate533 total
  • Zoledronic acidReclast, Zometabisphosphonate
    1 major102 moderate113 total
  • ZolmitriptanZomigtriptan
    75 major14 moderate99 total
  • ZolpidemAmbien, Edluarsedative-hypnotic
    201 major56 moderate262 totalFacts
  • ZonisamideZonegrananticonvulsant
    123 major244 moderate397 total