Diltiazem and Pravastatin interaction
Diltiazem and Pravastatin: the Diltiazem prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Diltiazem (DILTIAZEM HYDROCHLORIDE in SODIUM CHLORIDE) label · effective 2025-04-15
• Statins: Avoid statins metabolized by CYP3A4.
Statins Increased risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4.
When possible, use a non-CYP3A4-metabolized statin with diltiazem.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.