Bempedoic acid and Pravastatin interaction
Bempedoic acid and Pravastatin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Bempedoic acid (Nexletol) label · effective 2026-06-25
Intervention: Avoid concomitant use of NEXLETOL with pravastatin greater than 40 mg.
Pravastatin: Avoid concomitant use of NEXLETOL with pravastatin greater than 40 mg.
Pravastatin Clinical Impact: Concomitant use of NEXLETOL with pravastatin causes an increase in pravastatin concentration and may increase the risk of pravastatin-related myopathy [see Clinical Pharmacology (12.3) ] .
From the Pravastatin (Pravastatin Sodium) label · effective 2026-08-17
Pravastatin sodium plasma levels can be significantly increased with concomitant administration of inhibitors of OATP1B1.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.