Elexacaftor, tezacaftor, and ivacaftor and Sirolimus interaction
Elexacaftor, tezacaftor, and ivacaftor and Sirolimus: the Elexacaftor, tezacaftor, and ivacaftor prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Elexacaftor, tezacaftor, and ivacaftor (Trikafta) label · effective 2026-06-22
When used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index such as cyclosporine, everolimus, sirolimus and tacrolimus, caution and appropriate monitoring should be used [see Clinical Pharmacology (12.3) ] .
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.