Esomeprazole and Nirmatrelvir and ritonavir interaction

Esomeprazole and Nirmatrelvir and ritonavir: the Esomeprazole prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Esomeprazole (NEXIUM) label · effective 2025-12-19

Moderate

Ritonavir-containing products : see prescribing information for specific drugs Voriconazole Clinical Impact: Increased exposure of esomeprazole [see Clinical Pharmacology (12.3) ].

Drug interactionsnames Nirmatrelvir and ritonavirView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.