Nirmatrelvir and ritonavir and Sitagliptin and metformin interaction
Nirmatrelvir and ritonavir and Sitagliptin and metformin: the Nirmatrelvir and ritonavir prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Moderate
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Nirmatrelvir and ritonavir (Paxlovid) label · effective 2026-02-19
Moderate
Dipeptidyl peptidase 4 (DPP4) inhibitors saxagliptin ↑ saxagliptin Dosage adjustment of saxagliptin is recommended.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.