Norethindrone and ethinyl estradiol and Perampanel interaction
Norethindrone and ethinyl estradiol and Perampanel: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Norethindrone and ethinyl estradiol (Lo Loestrin Fe) label · effective 2025-03-07
CYP3A4 inhibitors such as itraconazole or ketoconazole may increase plasma hormone levels.
From the Perampanel (Fycompa) label · effective 2024-01-05
Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel ( 7.1 )
Contraceptives With concomitant use, FYCOMPA at a dose of 12 mg per day reduced levonorgestrel exposure by approximately 40% [see Clinical Pharmacology (12.3) ] .
Use of FYCOMPA with contraceptives containing levonorgestrel may render them less effective.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.