Silver sulfadiazine and Sulfamethoxazole and trimethoprim interaction
Silver sulfadiazine and Sulfamethoxazole and trimethoprim: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sulfamethoxazole and trimethoprim (SULFATRIM) label · effective 2026-01-05
Like other sulfonamide-containing drugs, sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics.
From the Silver sulfadiazine label · effective 2024-12-31
There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.