Sitagliptin and Sitagliptin and metformin interaction
Sitagliptin and Sitagliptin and metformin: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sitagliptin (JANUVIA) label · effective 2026-07-08
Use caution in a patient with a history of angioedema with another DPP-4 inhibitor because it is unknown whether such patients will be predisposed to angioedema with JANUVIA.
Heart failure : Heart failure has been observed with two other members of the DPP-4 inhibitor class.
If a hypersensitivity reaction is suspected, discontinue JANUVIA, assess for other potential causes for the event, and institute alternative treatment for diabetes. [See Adverse Reactions (6.2) .] Angioedema has also been reported with other DPP-4 inhibitors.
From the Sitagliptin and metformin (JANUMET XR) label · effective 2026-08-11
Use caution in a patient with a history of angioedema to another DPP-4 inhibitor because it is unknown whether such patients will be predisposed to angioedema with JANUMET XR.
Heart Failure: Has been observed with two other members of the DPP-4 inhibitor class.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.