تداخلات إنالابريل وهيدروكلوروثيازيد

…of active abnormal bleeding within the previous 30 days Severe hypertension (systolic blood pressure >200 mm Hg or diastolic blood pressure >110 mm Hg) not adequately controlled on antihypertensive therapy Major surgery within the preceding 6 weeks History of stroke within 30 days or any history of hemorrhagic stroke Current or planned administration of another… (نشرة إبتيفيباتيد، موانع الاستعمال)

…• serum creatinine > 2.0 mg/dL in males or >1.8 mg/dL in females, • creatinine clearance < 50 mL/min, or • concomitant administration of potassium supplements or potassium-sparing diuretics (e.g., amiloride, spironolactone, or triamterene) [see Warnings and Precautions (5.1) , Adverse Reactions (6.2) , Drug Interactions (7) , and Clinical Pharmacology (12.3)… (نشرة إبليرينون، موانع الاستعمال)

In patients whose renal function may depend on the activity of the renin-angiotensin-aldosterone system (e.g., patients with severe congestive heart failure), treatment with ACE inhibitors has been associated with oliguria and/or progressive azotemia and (rarely) with acute renal failure and/or death. (نشرة إربيسارتان وهيدروكلوروثيازيد، التحذيرات والاحتياطات)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

هذه الأدوية تقلّل إطراح البوتاسيوم؛ وإضافة مكملات البوتاسيوم أو بدائل الملح قد تسبب فرط بوتاسيوم الدم، وهو يؤثر في نظم القلب. (NIH Office of Dietary Supplements, Potassium)

Do not co-administer aliskiren with VASERETIC in patients with diabetes (see PRECAUTIONS, Drug Interactions ). (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Do not administer VASERETIC within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see WARNINGS ) . (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Hyperkalemia occurs commonly (about 10%) when amiloride is used without a kaliuretic diuretic. (نشرة أميلوريد، تحذير مؤطر)

…sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include those with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (نشرة إنالابريلات، التحذيرات)

Diuretics Eplerenone Contraindicated during and 2 weeks after TOLSURA treatment. (نشرة إيتراكونازول، التداخلات الدوائية)

Avoid diuretics or laxatives in patients with diarrhea. (نشرة إيرينوتيكان، التحذيرات والاحتياطات)

Avoid the concomitant use of ACE inhibitors with AFINITOR/AFINITOR DISPERZ [see Warnings and Precautions (5.4)] . (نشرة إيفيروليموس، التداخلات الدوائية)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

WARNING Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. (نشرة بوميتانيد، تحذير مؤطر)

Perindopril erbumine tablets are contraindicated in patients known to be hypersensitive (including angioedema) to this product or to any other ACE inhibitor. (نشرة بيريندوبريل، موانع الاستعمال)

Sodium bicarbonate injection is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction and in patients receiving diuretics known to produce a hypochloremic alkalosis. (نشرة بيكربونات الصوديوم، موانع الاستعمال)

CONTRAINDICATIONS Lotensin is contraindicated in patients: who are hypersensitive to benazepril or to any other ACE inhibitor with a history of angioedema with or without previous ACE inhibitor treatment Lotensin is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). (نشرة بينازيبريل، موانع الاستعمال)

Lotensin HCT is also contraindicated in patients who are hypersensitive to benazepril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs. (نشرة بينازيبريل وهيدروكلوروثيازيد، موانع الاستعمال)

…coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. [see Dosage and Administration ( 2.7 ), Drug Interactions ( 7.1 ),… (نشرة تادالافيل، التحذيرات والاحتياطات)

Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker ( 5.6 ) (نشرة تيلميسارتان، التحذيرات والاحتياطات)

Avoid concomitant use with an ACE inhibitor (5.6) (نشرة تيلميسارتان وأملوديبين، التحذيرات والاحتياطات)

Patients who received the combination of ARB and ACE inhibitor did not obtain any additional benefit (no additional reduction of risk of cardiovascular death, myocardial infarction, stroke, or hospitalization from heart failure) compared to ARB monotherapy or ACE inhibitor monotherapy, but experienced an increased incidence of renal dysfunction (e.g., acute renal… (نشرة تيلميسارتان وهيدروكلوروثيازيد، التداخلات الدوائية)

The risk of torsade de pointes is related to the extent of QTc prolongation, concomitant administration of QTc prolonging drugs, a history of torsade de pointes, pre-existing QTc interval prolongation, congestive heart failure, administration of potassium-wasting diuretics, or other conditions that result in hypokalemia or hypomagnesemia. (نشرة ثالث أكسيد الزرنيخ، التحذيرات والاحتياطات)

The concurrent use of gentamicin with potent diuretics, such as ethacrynic acid or furosemide, should be avoided, since certain diuretics by themselves may cause ototoxicity. (نشرة جنتاميسين، تحذير مؤطر)

CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. (نشرة حمض الإيثاكرينيك، موانع الاستعمال)

Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). (نشرة دروبيريدول، تحذير مؤطر)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

The concomitant use of hydrochlorothiazide (alone or in combinations such as with triamterene) with dofetilide is contraindicated (see PRECAUTIONS, Drug-Drug Interactions ) because this has been shown to significantly increase dofetilide plasma concentrations and QT interval prolongation. (نشرة دوفيتيليد، موانع الاستعمال)

CONTRAINDICATIONS PROGLYCEM is contraindicated in patients with: Functional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in PROGLYCEM, or other thiazides (نشرة ديازوكسيد، موانع الاستعمال)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Ramipril capsules is contraindicated in patients who are hypersensitive to this product or any other ACE inhibitor (e.g., a patient who has experienced angioedema during therapy with any other ACE inhibitor). (نشرة راميبريل، موانع الاستعمال)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

VASERETIC is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) (نشرة سترات البوتاسيوم، التداخلات الدوائية)

Table 2: Oral drugs that can be administered concomitantly with Ferric Citrate Tablets Amlodipine Aspirin Atorvastatin Calcitriol Clopidogrel Digoxin Diltiazem Doxercalciferol Enalapril Fluvastatin Glimepiride Levofloxacin Losartan Metoprolol Pravastatin Propranolol Sitagliptin Warfarin Oral drugs that have to be separated from Ferric Citrate Tablets and meals… (نشرة سترات الحديديك، التداخلات الدوائية)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Potassium-Sparing Diuretics Cyclosporine should not be used with potassium-sparing diuretics because hyperkalemia can occur. (نشرة سيكلوسبورين، التداخلات الدوائية)

Do not administer VASERETIC within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see WARNINGS ) . (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

CONTRAINDICATIONS Fosinopril sodium tablets are contraindicated in patients who are hypersensitive to this product or to any other angiotensin-converting enzyme inhibitor (e.g., a patient who has experienced angioedema with any other ACE inhibitor therapy). (نشرة فوسينوبريل، موانع الاستعمال)

Fosinopril sodium and hydrochlorothiazide is also contraindicated in patients who are hypersensitive to fosinopril, to any other ACE inhibitor, to hydrochlorothiazide, or other sulfonamide-derived drugs, or any other ingredient or component in the formulation. (نشرة فوسينوبريل وهيدروكلوروثيازيد، موانع الاستعمال)

Because the use of diuretics can accentuate the diminished intravascular volume, diuretics should be avoided except in the late phase of resolution as described below. (نشرة فوليتروبين، التحذيرات والاحتياطات)

CONTRAINDICATIONS Captopril tablets are contraindicated in patients who are hypersensitive to this product or any other angiotensin- converting enzyme inhibitor (e.g., a patient who has experienced angioedema during therapy with any other ACE inhibitor). (نشرة كابتوبريل، موانع الاستعمال)

Triple combination of candesartan cilexetil with an ACE-inhibitor and a mineralocorticoid receptor antagonist is generally not recommended. (نشرة كانديسارتان، التداخلات الدوائية)

Use CLOZARIL cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (e.g., dehydration, use of antihypertensive medications) [see Dosage and Administration ( 2.2 , 2.6 ), Warnings and Precautions ( 5.2 )]. (نشرة كلوزابين، تحذير مؤطر)

Because the use of diuretics can accentuate the diminished intravascular volume, avoid diuretics except in the late phase of resolution. (نشرة كوريوغونادوتروبين ألفا، التحذيرات)

…sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include patients with the following conditions or characteristics: heart failure, hyponatremia, high dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. (نشرة كينابريل، التحذيرات)

Other Antihypertensive Drugs When metolazone tablets, USP, are used with other antihypertensive drugs, particular care must be taken to avoid excessive reduction of blood pressure, especially during initial therapy. (نشرة ميتولازون، التحذيرات)

Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (نشرة إنالابريل وهيدروكلوروثيازيد، موانع الاستعمال)

Minoxidil should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents. (نشرة مينوكسيديل، تحذير مؤطر)

The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. (نشرة نيومايسين، تحذير مؤطر)

Diuretics The electrocardiogram (ECG) changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by β-agonists, especially when the recommended dose of the β-agonist is exceeded. (نشرة إبراتروبيوم وسالبوتامول، التداخلات الدوائية)

Antihypertensive Drugs Prevention or Management Increase the frequency of monitoring blood pressure and adjust atomoxetine oral solution dosage as clinically appropriate. (نشرة أتوموكسيتين، التداخلات الدوائية)

Because of its relative beta 1 selectivity, however, TENORMIN may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. (نشرة أتينولول، التحذيرات)

Because of its relative beta 1 -selectivity, however, atenolol and chlorthalidone may be used with caution in patients with bronchospastic disease who do not respond to or cannot tolerate, other antihypertensive treatment. (نشرة أتينولول وكلورثاليدون، التحذيرات)

…Precautions (5.6) and Adverse Reactions (6) ]. β-blockers, such as propranolol Cyclopropane or halogenated hydrocarbon anesthetics, such as halothane Antihistamines Thyroid hormones Diuretics Cardiac glycosides, such as digitalis glycosides Quinidine Drugs potentiating hypokalemic effects of epinephrine • Potassium depleting diuretics • Corticosteroids • Theophylline… (نشرة أدرينالين، التداخلات الدوائية)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes. (نشرة أرفورموتيرول، التداخلات الدوائية)

There was also a slightly greater proportion of patients on NUVIGIL requiring new or increased use of antihypertensive medications (2.9%) compared to patients on placebo (1.8%). (نشرة أرمودافينيل، التحذيرات والاحتياطات)

Antihypertensive Drugs Due to its alpha-adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. (نشرة أريبيبرازول، التداخلات الدوائية)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Antihypertensive agents clonidine, guanfacine, or moxonidine: Beta blockers also increase the risk of clonidine-, guanfacine-, or moxonidine-withdrawal rebound hypertension. (نشرة إسمولول، التداخلات الدوائية)

Although β-blockers should be avoided in overt cardiac failure, acebutolol can be used with caution in patients with a history of heart failure who are controlled with digitalis and/or diuretics. (نشرة أسيبوتولول، التحذيرات)

Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (نشرة إسيتالوبرام، التحذيرات والاحتياطات)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients… (نشرة أسينابين، التحذيرات والاحتياطات)

• Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 ) (نشرة أفانافيل، التحذيرات والاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In the post-marketing setting, there have been reports of angioedema in patients (primarily patients with AIS) receiving concomitant angiotensin-converting enzyme inhibitors. [see Warnings and Precautions (5.2) ]. (نشرة ألتيبلاز، التداخلات الدوائية)

Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 ) (نشرة ألفوزوسين، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hypersensitivity reactions to allopurinol tablets may be increased in patients with decreased kidney function receiving thiazide diuretics and allopurinol tablets concurrently. (نشرة ألوبيورينول، التحذيرات والاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Symptomatic hypotension is most likely to occur in patients who have heart failure, severe aortic or mitral stenosis, obstructive hypertrophic cardiomyopathy or have been volume or salt depleted as a result of diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. (نشرة أملوديبين وبينازيبريل، التحذيرات والاحتياطات)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Ethacrynic Acid, Furosemide, Urea, or Mannitol Some diuretics can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. (نشرة أميكاسين، التداخلات الدوائية)

Give special attention to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or in patients receiving concomitant diuretics and laxatives. (نشرة أميودارون، التحذيرات والاحتياطات)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (نشرة إنالابريل، التحذيرات والاحتياطات)

Drug Interactions Other Antihypertensives: Indapamide may add to or potentiate the action of other antihypertensive drugs. (نشرة إنداباميد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

…of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications) where the occurrence of syncope, or hypotension and/or bradycardia might put the patient at increased medical risk. (نشرة أولانزابين، التحذيرات والاحتياطات)

…and fluoxetine capsules should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (نشرة أولانزابين وفلوكسيتين، التحذيرات والاحتياطات)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (نشرة أوميبرازول، التحذيرات والاحتياطات)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions ( 6.2 )] . (نشرة أوميبرازول وبيكربونات الصوديوم، التحذيرات والاحتياطات)

• Diuretics: Use with caution. (نشرة أوميكليدينيوم وفيلانتيرول، التداخلات الدوائية)

Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (نشرة إيبوبروستينول، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Following initiation and titration of Epogen, approximately 25% of patients on dialysis required initiation of or increases in antihypertensive therapy; hypertensive encephalopathy and seizures have been reported in patients with CKD receiving Epogen. (نشرة إيبويتين ألفا، التحذيرات والاحتياطات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (نشرة إيزوميبرازول، التحذيرات والاحتياطات)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (نشرة إيلوبيريدون، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with imipramine hydrochloride tablets. (نشرة إيميبرامين، التحذيرات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SNRIs and SSRIs. [see Use in Specific Populations ( 8.5 )]. (نشرة باروكسيتين، التحذيرات والاحتياطات)

The risk may be increased when Paricalcitol Injection is used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (نشرة باريكالسيتول، التحذيرات والاحتياطات)

Monitor blood pressure as clinically indicated and initiate and adjust antihypertensive therapy as appropriate. (نشرة بازوبانيب، التحذيرات والاحتياطات)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Use ERZOFRI with caution in patients with known cardiovascular disease (e.g., heart failure, history of myocardial infarction or ischemia, conduction abnormalities), cerebrovascular disease, or conditions that predispose the patient to hypotension (e.g., dehydration, hypovolemia, and treatment with antihypertensive medications). (نشرة باليبيريدون، التحذيرات والاحتياطات)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (نشرة بانتوبرازول، التحذيرات والاحتياطات)

Syncopal episodes have usually occurred within 30 to 90 minutes of the initial dose of the drug; occasionally, they have been reported in association with rapid dosage increases or the introduction of another antihypertensive drug into the regimen of a patient taking high doses of prazosin hydrochloride capsules. (نشرة برازوسين، التحذيرات)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (نشرة بروكلوربيرازين، الاحتياطات)

Central Nervous System (CNS) depressants Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.). Antihypertensive drugs Sympathomimetic may reduce the effects of antihypertensive drugs. (نشرة برومفينيرامين وسودوإيفيدرين وديكستروميثورفان، التداخلات الدوائية)

Use caution in patients taking antihypertensive medications. (نشرة بروموكريبتين، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In addition, patients who are taking other drugs associated with angioedema (e.g., angiotensin converting enzyme inhibitors [ACE-inhibitors]) may be at increased risk of developing angioedema. (نشرة بريغابالين، التحذيرات والاحتياطات)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medication), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (نشرة بريكسبيبرازول، التحذيرات والاحتياطات)

Antihypertensives/Cardiac Glycosides Because brimonidine tartrate ophthalmic solution 0.1% and 0.15% may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate ophthalmic solution 0.1% and 0.15% is advised. (نشرة بريمونيدين، التداخلات الدوائية)

Antihypertensives/Cardiac Glycosides Because brimonidine tartrate/timolol maleate ophthalmic solution may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with brimonidine tartrate/timolol maleate ophthalmic solution is advised. (نشرة بريمونيدين وتيمولول، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Small decreases in blood pressure have been observed in some patients treated with pentoxifylline extended-release tablets; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. (نشرة بنتوكسيفيلين، التداخلات الدوائية)

Amphetamines may decrease the hypotensive effect of antihypertensives. (نشرة بنزفيتامين، التداخلات الدوائية)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Diuretics: Use with caution. (نشرة بوديزونيد وفورموتيرول، التداخلات الدوائية)

Hypotension: Use caution when treating patients taking antihypertensives, with a history of syncope, or with dehydration. (نشرة بورتيزوميب، التحذيرات والاحتياطات)

Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Because of its relative beta 1 -selectivity, however, BISOPROLOL FUMARATE may be used with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment. (نشرة بيسوبرولول، التحذيرات)

Because of the relative beta 1 -selectivity of bisoprolol fumarate, bisoprolol fumarate and hydrochlorothiazide tablets may be used with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment. (نشرة بيسوبرولول وهيدروكلوروثيازيد، التحذيرات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Although beta-blockers should be avoided in overt congestive heart failure, if necessary, pindolol tablets can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (نشرة بيندولول، التحذيرات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

• Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. (نشرة تاكروليموس، التحذيرات والاحتياطات)

Nifedipine, Atenolol, Enalapril Dosage adjustments are not necessary when tamsulosin hydrochloride capsules are administered concomitantly with nifedipine, atenolol, or enalapril [see clinical pharmacology ( 12.3 )] . (نشرة تامسولوسين، التداخلات الدوائية)

Concomitant use with an antihypertensive may require a reduction in the dose of the antihypertensive drug. (نشرة ترازودون، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Like other ACE inhibitors, trandolapril has only rarely been associated with symptomatic hypotension in uncomplicated hypertensive patients. (نشرة تراندولابريل، التحذيرات)

WARNINGS General Enalapril Maleate Hypotension: Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

WARNINGS General Enalapril Maleate Hypotension: Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (نشرة تريفلوبيرازين، الاحتياطات)

In patients with hypertension on antihypertensive therapy, TLANDO increased the mean systolic/diastolic BP by 4.8/1.6 mm Hg from baseline. [see Adverse Reactions ( 6.1 )] . (نشرة تستوستيرون، التحذيرات والاحتياطات)

Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. (نشرة توبرامايسين، التداخلات الدوائية)

Hydrochlorothiazide (HCTZ) Topiramate C max and AUC increased when HCTZ was added to immediate-release topiramate. (نشرة توبيرامات، التداخلات الدوائية)

WARNINGS General Enalapril Maleate Hypotension: Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Drugs that decrease renal calcium excretion, e.g., thiazide diuretics, may increase the risk of hypercalcemia in patients receiving FARESTON. (نشرة توريميفين، التداخلات الدوائية)

Co-administration of diuretics also increases the risk of too rapid correction of serum sodium and such patients should undergo close monitoring of serum sodium. (نشرة تولفابتان، التحذيرات والاحتياطات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Risk of Hypotension with Concomitant Use of Other Antihypertensive Agents and Phospodiesterase Type 5 Inhibitors (PDE5-I): Concomitant administration of TEZRULY with antihypertensives or phosphodiesterase-5 (PDE-5) inhibitors can result in additive blood pressure lowering effects and symptomatic hypotension (5.3). (نشرة تيرازوسين، التحذيرات والاحتياطات)

Diuretics The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. (نشرة تيربوتالين، الاحتياطات)

Anti-diabetic drugs (oral agents and insulin) Dosage adjustment of the anti-diabetic drug may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Patients receiving coadministration of ACE inhibitor and mTOR (mammalian target of rapamycin) inhibitor (e.g., temsirolimus, sirolimus, everolimus) therapy or a neprilysin inhibitor may be at increased risk for angioedema (see PRECAUTIONS ). (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

OATP2B1 Substrates: Potential for reduced exposure of the concomitant drug (e.g., enalapril). (نشرة تينابانور، التداخلات الدوائية)

Elderly patients and those receiving diuretic therapy are at increased risk of acute renal failure. (نشرة حمض الزوليدرونيك، التحذيرات والاحتياطات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS. (نشرة دروسبيرينون وإيثينيل إستراديول، التحذيرات والاحتياطات)

Nifedipine, Atenolol, Enalapril Tamsulosin Dosage adjustments are not necessary when tamsulosin is administered concomitantly with nifedipine, atenolol, or enalapril [see Clinical Pharmacology (12.3) ]. (نشرة دوتاستيريد وتامسولوسين، التداخلات الدوائية)

Risk may be increased when used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds. (نشرة دوكسيركالسيفيرول، التحذيرات والاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

The risk of BP decreases may be greater in patients taking concomitant medications that induce orthostatic hypotension (such as antihypertensives) or are potent CYP1A2 inhibitors [see Drug Interactions ( 7.1 )] and in patients taking duloxetine delayed-release capsules at doses above 60 mg daily. (نشرة دولوكسيتين، التحذيرات والاحتياطات)

The pressor effects of diethylpropion and those of other drugs may be additive when the drugs are used concomitantly; conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa). (نشرة ديثيل بروبيون، التداخلات الدوائية)

Hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis (e.g., increased ventricular irritability). (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk [see Use in Specific Populations (8.5) and Clinical Pharmacology (12.3) ] . (نشرة ديسفينلافاكسين، التحذيرات والاحتياطات)

…Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin and carbamazepine). (نشرة ديسموبريسين، التداخلات الدوائية)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with NORPRAMIN. (نشرة ديسيبرامين، التحذيرات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (نشرة ديكسلانسوبرازول، التحذيرات والاحتياطات)

• Antihypertensive Drugs: Monitor blood pressure. (نشرة ديكسميثيل فينيدات، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ]. (نشرة رابيبرازول، التحذيرات والاحتياطات)

Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Clinically significant hypotension has been observed with concomitant use of oral RISPERDAL and antihypertensive medication. (نشرة ريسبيريدون، التحذيرات والاحتياطات)

Decrease exposure Other Drugs Enalapril Decrease active metabolite exposure Chloramphenicol Concomitant use with rifampin in 2 children Decrease exposure Clarithromycin Decrease exposure Dapsone Rifampin has been shown to increase the clearance of dapsone and, accordingly, decrease dapsone exposure. (نشرة ريفامبيسين، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Consider the potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensives or strong CYP and P-gp/BCRP inhibitors [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] . (نشرة ريوسيغوات، التحذيرات والاحتياطات)

Hypokalemia may result from diuretic therapy, diarrhea, and other causes. (نشرة زيبراسيدون، التحذيرات والاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Diuretics: Use with caution. (نشرة سالبوتامول، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

• Diuretics: Use with caution. (نشرة سالميتيرول، التداخلات الدوائية)

WARNINGS General Enalapril Maleate Hypotension: Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

WARNINGS General Enalapril Maleate Hypotension: Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Prolonged Neuromuscular Block in Patients with Hypokalemia or Hypocalcemia Neuromuscular blockade may be prolonged in patients with hypokalemia (e.g., after severe vomiting, diarrhea, digitalisation and diuretic therapy) or hypocalcemia (e.g., after massive transfusions). (نشرة سكسينيل كولين، التحذيرات والاحتياطات)

Special attention should be given to electrolyte and acid-base balance in patients experiencing severe or prolonged diarrhea or patients receiving concomitant diuretic drugs. (نشرة سوتالول، التحذيرات والاحتياطات)

Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy. (نشرة سورافينيب، التحذيرات والاحتياطات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Initiate and/or adjust antihypertensive therapy as appropriate. (نشرة سونيتينيب، التحذيرات والاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Elderly patients, patients taking diuretics, and those who are volume depleted may be at greater risk for developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (نشرة سيتالوبرام، التحذيرات والاحتياطات)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs [see Use in Specific Populations ( 8.5 )] . (نشرة سيرترالين، التحذيرات والاحتياطات)

Patients receiving coadministration of ACE inhibitor and mTOR (mammalian target of rapamycin) inhibitor (e.g., temsirolimus, sirolimus, everolimus) therapy or a neprilysin inhibitor may be at increased risk for angioedema (see PRECAUTIONS ). (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Drug Interactions Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibacterial drugs or potent diuretics such as furosemide. (نشرة سيفتازيديم، التداخلات الدوائية)

Diuretics: Nephrotoxicity has been reported with concomitant administration of cephalosporins with potent diuretics such as furosemide. (نشرة سيفيبيم، التداخلات الدوائية)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Increase the dose of diuretics as needed [see Adverse Reactions (6) ] . (نشرة سيكلوسيليكات الزركونيوم الصوديوم، التحذيرات والاحتياطات)

…inhibitors: ACE inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ● Anthracyclines ● Cytarabine ● Pentostatin ● Radiation therapy of the cardiac region ● Trastuzumab Increased pulmonary toxicity… (نشرة سيكلوفوسفاميد، التداخلات الدوائية)

Caution is advised when SILDENAFIL ORAL FILM is co-administered with alpha-blockers or antihypertensives. (نشرة سيلدينافيل، التحذيرات والاحتياطات)

However, patients in the Phase 3 clinical studies taking concomitant antihypertensive medications with silodosin capsules did not experience a significant increase in the incidence of syncope, dizziness, or orthostasis. (نشرة سيلودوسين، التحذيرات والاحتياطات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Vardenafil hydrochloride tablets can potentiate the hypotensive effects of nitrates, alpha- blockers, and antihypertensives. (نشرة فاردينافيل، التداخلات الدوائية)

Drugs Suspected of Causing SIADH Use with drugs suspected of causing SIADH (e.g., SSRIs, tricyclic antidepressants, haloperidol, chlorpropamide, enalapril, methyldopa, pentamidine, vincristine, cyclophosphamide, ifosfamide, felbamate) may increase the pressor effect in addition to the antidiuretic effect of Vasostrict ® . (نشرة فازوبريسين، التداخلات الدوائية)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Diuretics: Use with caution. (نشرة فلوتيكازون وسالميتيرول، التداخلات الدوائية)

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. (نشرة فلودروكورتيزون، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk. (نشرة فلوفوكسامين، التحذيرات والاحتياطات)

Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (نشرة فلوكسيتين، التحذيرات والاحتياطات)

Hydrochlorothiazide In a pharmacokinetic interaction study, coadministration of multiple-dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%. (نشرة فلوكونازول، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Also, patients taking diuretics or who are otherwise volume-depleted can be at greater risk. (نشرة فورتيوكسيتين، التحذيرات والاحتياطات)

• Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes. (نشرة فورموتيرول، التداخلات الدوائية)

WARNINGS General Enalapril Maleate Hypotension: Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

When diuretics are indicated, thiazides are recommended over loop diuretics because the latter inhibit renal tubular secretion, and may impair elimination of FOSCAVIR, potentially leading to toxicity. (نشرة فوسكارنت، التداخلات الدوائية)

مدرات البول الثيازيدية تقلّل إطراح الكالسيوم؛ واجتماع ذلك مع مكملات فيتامين د والكالسيوم قد يؤدي إلى فرط كالسيوم الدم، وخصوصًا لدى كبار السن. (NIH Office of Dietary Supplements, Vitamin D)

Control patients with milder ventricular dysfunction, if possible, with optimum doses of digitalis and/or diuretics before verapamil treatment is started [see Drug Interactions ( 7.5 )] . (نشرة فيراباميل، التحذيرات والاحتياطات)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia with SSRIs and SNRIs [see Use in Specific Populations ( 8.5 )] . (نشرة فيلازودون، التحذيرات والاحتياطات)

Concomitant administration of hydrochlorothiazide alone with topiramate alone has been shown to increase the C max and AUC of topiramate by 27% and 29%, respectively. (نشرة فينترمين وتوبيرامات، التداخلات الدوائية)

Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] . (نشرة فينلافاكسين، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

…hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine Phenelzine sulfate should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result. (نشرة فينيلزين، التحذيرات)

Antagonistic Effects (decrease in BIORPHEN blood pressure effect) can occur with α-adrenergic antagonists, phosphodiesterase Type 5 inhibitors, mixed α- and β-receptor antagonists, calcium channel blockers, benzodiazepines and ACE inhibitors, centrally acting sympatholytic agents. (نشرة فينيليفرين، التداخلات الدوائية)

Elderly patients and patients treated with diuretics are at greater risk of developing hyponatremia. (نشرة كاربامازيبين، التحذيرات والاحتياطات)

Symptomatic postural hypotension has occurred when carbidopa, given with levodopa or carbidopa-levodopa combination products, was added to the treatment of a patient receiving antihypertensive drugs. (نشرة كاربيدوبا، التداخلات الدوائية)

Antihypertensive drugs: May cause symptomatic postural hypotension. (نشرة كاربيدوبا وليفودوبا، التداخلات الدوائية)

Antihypertensive Agents Symptomatic postural hypotension has occurred when carbidopa/levodopa was added to the treatment of patients receiving antihypertensive drugs. (نشرة كاربيدوبا وليفودوبا وإنتاكابون، التداخلات الدوائية)

If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration (2) ] . (نشرة كارفيديلول، التحذيرات والاحتياطات)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive medications), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and… (نشرة كاريبرازين، التحذيرات والاحتياطات)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Thiazides Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. (نشرة كالسيتريول، التداخلات الدوائية)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. (نشرة كلوربرومازين، الاحتياطات)

Effect of chlorthalidone on other drugs Chlorthalidone may add to or potentiate the action of other antihypertensive drugs. (نشرة كلورثاليدون، التداخلات الدوائية)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Thiazides may add to or potentiate the action of other antihypertensive drugs. (نشرة كلوروثيازيد، التحذيرات)

Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Drugs That Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). (نشرة كلوريد الكالسيوم، التداخلات الدوائية)

Consider use of diuretics and/or albumin. (نشرة كلوفارابين، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Quetiapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), cerebrovascular disease, or conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications). (نشرة كويتيابين، التحذيرات والاحتياطات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Diuretics eplerenone The potential increase in plasma concentrations of eplerenone when coadministered with ketoconazole tablets may increase the risk of hyperkalemia and hypotension. (نشرة كيتوكونازول، التداخلات الدوائية)

Like other ACE inhibitors, quinapril has been only rarely associated with hypotension in uncomplicated hypertensive patients. (نشرة كينابريل وهيدروكلوروثيازيد، التحذيرات)

Drugs that alkalinize the urine ( carbonic-anhydrase inhibitors, sodium bicarbonate, thiazide diuretics ) reduce renal elimination of quinidine. (نشرة كينيدين، التداخلات الدوائية)

Examples of relevant classes of compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials. (نشرة لانثانوم، التداخلات الدوائية)

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ] . (نشرة لانسوبرازول، التحذيرات والاحتياطات)

Patients at increased risk of these adverse reactions or at increased risk of developing complications from hypotension include those with dehydration, hypovolemia, treatment with antihypertensive medication, history of cardiovascular disease (e.g., heart failure, myocardial infarction, ischemia, or conduction abnormalities), history of cerebrovascular disease,… (نشرة لوراسيدون، التحذيرات والاحتياطات)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Enalapril Maleate Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (e.g., elderly patients, patients with dehydration, hypovolemia, and concomitant treatment with antihypertensive drugs), patients with known cardiovascular disease (history of myocardial infarction, ischemic heart disease, heart failure, or conduction abnormalities), and patients… (نشرة لوماتيبيرون، التحذيرات والاحتياطات)

Lithium generally should not be given with thiazides (see PRECAUTIONS, Drug Interactions, Enalapril Maleate and Hydrochlorothiazide ). (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Patients at risk of excessive hypotension include those with the following conditions or characteristics: heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology. (نشرة ليزينوبريل، التحذيرات والاحتياطات)

When a diuretic is added to the therapy of a patient receiving lisinopril, an additional antihypertensive effect is usually observed (see DOSAGE AND ADMINISTRATION ). (نشرة ليزينوبريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Diuretics The ECG changes or hypokalemia that may result from the administration of non-potassium-sparing diuretics (such as loop and thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. (نشرة ليفوسالبوتامول، التداخلات الدوائية)

Also, patients taking diuretics or who are otherwise volume depleted can be at greater risk. (نشرة ليفوميلناسيبران، التحذيرات والاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

Monitor serum sodium levels regularly in the elderly, in patients taking diuretics, and in other patients at risk of hyponatremia and/or SIADH while taking Linezolid injection. (نشرة لينزوليد، التحذيرات والاحتياطات)

However, a retrospective analysis of the use of antihypertensive medication in these studies showed that a greater proportion of patients on PROVIGIL required new or increased use of antihypertensive medications (2.4%) compared to patients on placebo (0.7%). (نشرة مودافينيل، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hypotension Moexipril hydrochloride can cause symptomatic hypotension, although, as with other ACE inhibitors, this is unusual in uncomplicated hypertensive patients treated with moexipril hydrochloride alone. (نشرة موكسيبريل، التحذيرات)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

If such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of Metoprolol Tartrate Tablets [see Dosage and Administration (2) ]. (نشرة ميتوبرولول، التحذيرات والاحتياطات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) Possible increased responsiveness to the muscle relaxant. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Antihypertensive Drugs: Monitor blood pressure. (نشرة ميثيل فينيدات، التداخلات الدوائية)

Elderly patients, patients taking diuretics, and those who are volume-depleted may be at greater risk of developing hyponatremia [see Use in Specific Populations (8.5) ] . (نشرة ميرتازابين، التحذيرات والاحتياطات)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (نشرة إنالابريل وهيدروكلوروثيازيد، الاحتياطات)

The action of Mecamylamine HCl may be potentiated by anesthesia, other antihypertensive drugs and alcohol. (نشرة ميكاميلامين، التداخلات الدوائية)

Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Geriatric Use ( 8.5 )] . (نشرة ميلناسيبران، التحذيرات والاحتياطات)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Although beta-blockers should be avoided in overt congestive heart failure, if necessary, they can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. (نشرة نادولول، التحذيرات)

Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Antihypertensive Therapy Niacin may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension. (نشرة نياسين، التداخلات الدوائية)

Antihypertensives: Possible additive hypotensive effects. (نشرة نيتروغليسرين، التداخلات الدوائية)

ACE Inhibitors Benazepril: In healthy volunteers receiving single dose of 20 mg nifedipine ER and benazepril 10 mg, the plasma concentrations of benazeprilat and nifedipine in the presence and absence of each other were not statistically significantly different. (نشرة نيفيديبين، التداخلات الدوائية)

Blood Pressure Lowering Drugs Nimodipine may increase the blood pressure lowering effect of concomitantly administered anti-hypertensives such as diuretics, beta-blockers, ACE inhibitors, angiotensin receptor blockers, other calcium channel blockers, α-adrenergic blockers, PDE5 inhibitors, and α-methyldopa. (نشرة نيموديبين، التداخلات الدوائية)

Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (نشرة هالوبيريدول، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Non-steroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration… (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics: Alcohol, barbiturates, or narcotics Potentiation of orthostatic hypotension may occur. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Concurrent use with potassium-containing medications, potassium-sparing diuretics and angiotensin-converting enzyme inhibitors (ACE inhibitors) may result in hyperkalemia and cardiac arrhythmias or cardiac arrest. (نشرة يوديد البوتاسيوم، التداخلات الدوائية)

Where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided (see ADVERSE REACTIONS ). (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Use with Angiotensin-Converting Enzyme Inhibitors: The use of angiotensin-converting enzyme inhibitors to control hypertension in patients on azathioprine has been reported to induce anemia and severe leukopenia. (نشرة أزاثيوبرين، التداخلات الدوائية)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In addition to discontinuation of the drug, diuretic therapy may be required. (نشرة إستروجينات مؤسترة وميثيل تستوستيرون، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

مدرات البول الثيازيدية تزيد فقدان الزنك في البول مع الاستعمال الطويل الأمد. (NIH Office of Dietary Supplements, Zinc)

مدرات البول الثيازيدية تقلّل إطراح الكالسيوم، ولذلك فإن المتناول المرتفع من الكالسيوم قد يرفع كالسيوم الدم. (NIH Office of Dietary Supplements, Calcium)

الاستعمال الطويل الأمد لمدرات العروة ومدرات البول الثيازيدية يزيد فقدان المغنيسيوم في البول. (NIH Office of Dietary Supplements, Magnesium)

Coadministration of 1 Dyazide (triamterene/hydrochlorothiazide) resulted in a higher plasma amantadine hydrochloride concentration in a 61-year old man receiving amantadine hydrochloride 100 mg TID for Parkinson's disease. (نشرة أمانتادين، التداخلات الدوائية)

Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (نشرة أمبريسنتان، التحذيرات والاحتياطات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Examples: α-adrenergic antagonists, β-adrenergic receptor antagonists, reserpine, quinidine, mephentermine Other Drug Interactions G u anethidine C linical Impact: Ephedrine may inhibit the neuron blockage produced by guanethidine, resulting in loss of antihypertensive effectiveness. (نشرة إيفيدرين، التداخلات الدوائية)

ACE Inhibitors FIRAZYR is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where FIRAZYR may attenuate the antihypertensive effect of ACE inhibitors. (نشرة إيكاتيبانت، التداخلات الدوائية)

Weigh patients regularly and manage unexpected rapid weight gain by drug interruption and diuretics. (نشرة إيماتينيب، التحذيرات والاحتياطات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Protriptyline may block the antihypertensive effect of guanethidine or similarly acting compounds. (نشرة بروتريبتيلين، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided (see ADVERSE REACTIONS ). (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided (see ADVERSE REACTIONS ). (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Patients required intervention with a diuretic, fluid management, or hospitalization for decompensating heart failure. (نشرة بوسنتان، التحذيرات والاحتياطات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, phenytoins, thiazide diuretics, and calcium channel blockers. (نشرة تيربينافين، التداخلات الدوائية)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (نشرة داساتينيب، التحذيرات والاحتياطات)

Hypokalemia and Hypomagnesemia with Potassium-Depleting Diuretics Hypokalemia or hypomagnesemia may occur with concomitant administration of potassium-depleting diuretics. (نشرة درونيدارون، التحذيرات والاحتياطات)

Patients developing peripheral edema may be treated with standard measures, e.g., salt restriction, oral diuretic(s). (نشرة دوسيتاكسيل، التحذيرات والاحتياطات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. (نشرة ديسوجيستريل وإيثينيل إستراديول، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Examples of alkalinizing agents include gastrointestinal alkalinizing agents (e.g., sodium bicarbonate) and urinary alkalinizing agents (e.g. acetazolamide, some thiazides). (نشرة ديكستروأمفيتامين، التداخلات الدوائية)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Drug Interactions Probenecid Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline,… (نشرة سيدوفوفير، التداخلات الدوائية)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Drugs that may cause hypercalcemia: Vitamin D, vitamin A, thiazide diuretics, estrogen, calcipotriene and teriparatide administration may cause hypercalcemia. (نشرة غلوكونات الكالسيوم، التداخلات الدوائية)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Flecainide acetate has been used in a large number of patients receiving diuretics without apparent interaction. (نشرة فليكاينيد، التداخلات الدوائية)

In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, ULORIC does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ]. (نشرة فيبوكسوستات، التداخلات الدوائية)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

…specific interaction studies were not performed, PROSCAR was concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory… (نشرة فيناستيريد، التداخلات الدوائية)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (نشرة كورتيكوتروبين، التداخلات الدوائية)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided (see ADVERSE REACTIONS ). (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Postmarketing cases of edema and fluid retention occurring within weeks of starting OPSUMIT, some requiring intervention with a diuretic or hospitalization for decompensated heart failure, have been reported [see Adverse Reactions (6.2) ] . (نشرة ماسيتنتان، التحذيرات والاحتياطات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In addition to discontinuation of the drug, diuretic therapy may be required. (نشرة ميثيل تستوستيرون، التحذيرات)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (نشرة ميكسيليتين، التداخلات الدوائية)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

…been observed in limited experience with patients in whom milrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements. (نشرة ميلرينون، التداخلات الدوائية)

The antihypertensive action of guanethidine and similar agents may be blocked. (نشرة نورتريبتيلين، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Other Cardiovascular Agents Enalapril has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (نشرة إنالابريل وهيدروكلوروثيازيد، التحذيرات)

Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (نشرة إنالابريل وهيدروكلوروثيازيد، التداخلات الدوائية)

Loop Diuretics Concomitant administration of a loop diuretic had no effect on the calcium-lowering action of pamidronate disodium. (نشرة باميدرونات، التداخلات الدوائية)

Commonly Administered Drugs: Population analysis showed that commonly administered drugs (e.g., selegiline, amantadine, tricyclic antidepressants, benzodiazepines, ibuprofen, thiazides, antihistamines, anticholinergics) did not affect the clearance of ropinirole. (نشرة روبينيرول، التداخلات الدوائية)

Table 5: Sevelamer Drug Interactions Oral drugs for which sevelamer did not alter the pharmacokinetics when administered concomitantly Digoxin Enalapril Iron Metoprolol Warfarin Oral drugs that have demonstrated interaction with sevelamer and are to be dosed separately from sevelamer carbonate Dosing Recommendations Ciprofloxacin Take at least 2 hours before… (نشرة سيفيلامير، التداخلات الدوائية)