Interaction Checker

Apraclonidine interactions

Apraclonidine (Iopidine), an alpha-adrenergic agonist has 10 documented interactions across the FDA labels and fact sheets we index: 9 major, 0 moderate, 1 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (9)

  • Clonidinealpha-adrenergic agonistMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

  • HyaluronidaseMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • IsoniazidantibioticMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

  • LinezolidantibioticMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

  • Methylene blueMAO inhibitorMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

  • PhenelzineMAO inhibitorMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

  • RasagilineMAO inhibitorMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

  • SelegilineMAO inhibitorMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

  • TranylcypromineMAO inhibitorMajor

    CONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine. (Apraclonidine label, Contraindications)

Minor mentions (1)

  • OxymetazolinedecongestantMinor

    Alpha-adrenergic agonists as a class may impact blood pressure. (Oxymetazoline label, Warnings and precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.