Interaction Checker

Benzonatate interactions

Benzonatate (Tessalon) has 29 documented interactions across the FDA labels and fact sheets we index: 0 major, 7 moderate, 22 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

What Benzonatate looks like

All 26 versions
Benzonatate 150 mg capsule: orange, 8 mm, imprinted 2.
2
150 mg · orange · capsule · 8 mm
Sportpharm
Benzonatate 200 mg capsule: yellow, 8 mm, imprinted 3.
3
200 mg · yellow · capsule · 8 mm
Sportpharm
Benzonatate 100 mg capsule: yellow, 8 mm, imprinted 1.
1
100 mg · yellow · capsule · 8 mm
Redpharm Drug
Benzonatate 100 mg capsule: yellow, 7 mm, imprinted 1.
1
100 mg · yellow · capsule · 7 mm
Sportpharm

Renderings from the FDA labels' product listings: color, shape, size, and imprint. 26 documented versions from 23 labelers.

Interactions from the label

Moderate interactions (7)

  • Desfluranegeneral anestheticModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

  • Etomidategeneral anestheticModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

  • Isofluranegeneral anestheticModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

  • KetamineCNS depressantModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

  • MethohexitalbarbiturateModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

  • PropofolCNS depressantModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

  • Sevofluranegeneral anestheticModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

Minor mentions (22)

  • Articaine and epinephrinelocal anestheticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • BenzphetamineCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Brompheniramine, pseudoephedrine, and dextromethorphanantihistamineMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Bupivacaine and epinephrinelocal anestheticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • DiethylpropionCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • DobutaminesympathomimeticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • DroxidopasympathomimeticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • EphedrinesympathomimeticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • EpinephrinesympathomimeticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Isoproterenolbeta-adrenergic agonistMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Lidocaine and epinephrinelocal anestheticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • MethamphetamineCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Midodrinealpha-adrenergic agonistMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Mirabegronbeta-adrenergic agonistMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • ModafinilCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • OxymetazolinedecongestantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • PhendimetrazineCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • PhentermineCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • PhenylephrinedecongestantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Prilocaine and epinephrinelocal anestheticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • PseudoephedrinedecongestantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Vibegronbeta-adrenergic agonistMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.