Interaction Checker

Benzonatate interactions

Benzonatate (Tessalon) has 11 documented interactions across the FDA labels and fact sheets we index: 0 major, 2 moderate, 9 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Moderate interactions (2)

  • KetamineCNS depressantModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

  • PropofolCNS depressantModerate

    PRECAUTIONS Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g. procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. (Benzonatate label, Precautions)

Minor mentions (9)

  • DroxidopasympathomimeticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • EpinephrinesympathomimeticMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Midodrinealpha-adrenergic agonistMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Mirabegronbeta-adrenergic agonistMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • ModafinilCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • PhentermineCNS stimulantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • PhenylephrinedecongestantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • PseudoephedrinedecongestantMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Vibegronbeta-adrenergic agonistMinor

    Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

Check Benzonatate against everything you take. Add your full list; every pair is checked at once.

Open in the checker

Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.