Bromocriptine interactions

Bromocriptine (Parlodel, Cycloset), a dopamine agonist has 282 documented interactions across the FDA labels and fact sheets we index: 85 major, 157 moderate, 40 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (85)

  • AlmotriptantriptanMajor

    Do not use almotriptan tablets within 24 hours of an ergotamine-containing, or ergot-type medication, or of another 5-HT 1 agonist, e.g., another triptan ( 4.5 , 4.6 ) (Almotriptan label, Contraindications)

  • AmiodaroneantiarrhythmicMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • AprepitantCYP3A4 inhibitorMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • AripiprazoleantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • AsenapineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • AtazanavirantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • BrexpiprazoleantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Bupivacainelocal anestheticMajor

    Avoid use of MARCAINE WITH EPINEPHRINE concomitantly with ergot-type oxytocic drugs [see Drug Interactions (7.3)]. (Bupivacaine label, Warnings and precautions)

  • Bupivacaine and epinephrinelocal anestheticMajor

    Avoid use of MARCAINE WITH EPINEPHRINE concomitantly with ergot-type oxytocic drugs [see Drug Interactions (7.3) ] . (Bupivacaine and epinephrine label, Warnings and precautions)

  • Cabergolinedopamine agonistMajor

    Use of bromocriptine, another dopamine agonist for this unapproved use has been associated with cases of hypertension, stroke, myocardial infarction, seizures, and death. (Cabergoline label, Warnings and precautions)

  • CariprazineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • CenobamateanticonvulsantMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Chloroprocainelocal anestheticMajor

    Vasopressors should not be used in the presence of ergot-type oxytocic drugs, since a severe persistent hypertension may occur. (Chloroprocaine label, Warnings)

  • ChlorpromazineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • CimetidineH2 blockerMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Clarithromycinmacrolide antibioticMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Clotrimazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • ClozapineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • CyclosporineimmunosuppressantMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • DarunavirantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Darunavir and cobicistatantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Diltiazemcalcium channel blockerMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • DronedaroneantiarrhythmicMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Droperidoldopamine antagonistMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Econazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • EfavirenzantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • EletriptantriptanMajor

    • Recent use (i.e., within 24 hours) of another 5-hydroxytryptamine 1 (5-HT 1 ) agonist, ergotamine-containing medication, or ergot-type medication such as dihydroergotamine (DHE) or methysergide [see Drug Interactions (7.1) ] . (Eletriptan label, Contraindications)

  • Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Erythromycinmacrolide antibioticMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • EverolimusimmunosuppressantMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Fluconazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • FluphenazineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • FosamprenavirantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • FosaprepitantCYP3A4 inhibitorMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • FrovatriptantriptanMajor

    Recent use (i.e., within 24 hours) of another 5-HT 1 agonist, an ergotamine containing or ergot-type medication such as dihydroergotamine (DHE) or methysergide [see Drug Interactions (7.1 , 7.2) ]. (Frovatriptan label, Contraindications)

  • HaloperidolantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • IloperidoneantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • ImatinibCYP3A4 inhibitorMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • IsoniazidantibioticMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Itraconazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • IvacaftorCYP3A4 inhibitorMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Ketoconazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • LenacapavirantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Lidocaine and epinephrinelocal anestheticMajor

    Avoid use of FLAVALTA concomitantly with ergot-type oxytocic drugs [see Drug Interactions (7.3) ]. (Lidocaine and epinephrine label, Warnings and precautions)

  • Lopinavir and ritonavirantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • LoxapineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • LumateperoneantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • LurasidoneantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Mepivacainelocal anestheticMajor

    Mepivacaine with epinephrine or other vasopressors should not be used concomitantly with ergot-type oxytocic drugs, because a severe persistent hypertension may occur. (Mepivacaine label, Warnings)

  • Metoclopramidedopamine antagonistMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Miconazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • MifepristoneCYP3A4 inhibitorMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Mirabegronbeta-adrenergic agonistMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • NaratriptantriptanMajor

    …Ischemic bowel disease [see Warnings and Precautions (5.5)] Uncontrolled hypertension [see Warnings and Precautions (5.8)] Recent use (i.e., within 24 hours) of another 5-HT 1 agonist, ergotamine-containing medication, ergot-type medication (such as dihydroergotamine or methysergide) [see Drug Interactions (7.1, 7.2)] Hypersensitivity to naratriptan tablets (angioedema… (Naratriptan label, Contraindications)

  • NefazodoneantidepressantMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • NitroglycerinnitrateMajor

    Therefore, patients receiving sublingual nitroglycerin should avoid ergotamine and related drugs or be monitored for symptoms of ergotism if this is not possible. (Nitroglycerin label, Drug interactions)

  • OlanzapineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Olanzapine and fluoxetineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • PalbociclibCYP3A4 inhibitorMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • PaliperidoneantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • PerampanelanticonvulsantMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • PerphenazineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • PimavanserinantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • PimozideantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Posaconazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • ProchlorperazineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • QuetiapineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • RanolazineQT-prolonging drugMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • RisperidoneantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • RitonavirantiretroviralMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • RizatriptantriptanMajor

    Recent use (i.e., within 24 hours) of another 5-HT 1 agonist, ergotamine-containing medication, or ergot-type medication (such as dihydroergotamine or methysergide) [see Drug Interactions (7.2 and 7.3) ] . (Rizatriptan label, Contraindications)

  • SumatriptantriptanMajor

    Also, there are limited clinical trial data supporting the safety of selective 5-hydroxytryptamine 1B (5-HT 1B ) agonists (e.g., sumatriptan) used concurrently with CYCLOSET, and the concomitant use of these agents with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Also, there are limited clinical trial data supporting the safety of selective 5-hydroxytryptamine 1B (5-HT 1B ) agonists (e.g., sumatriptan) used concurrently with CYCLOSET, and the concomitant use of these agents with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Suvorexantsedative-hypnoticMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • ThioridazineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • ThiothixeneantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Ticagrelorantiplatelet agentMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Tolcapone tablets is also contraindicated in patients with a history of nontraumatic rhabdomyolysis or hyperpyrexia and confusion possibly related to medication (see PRECAUTIONS: Events Reported With Dopaminergic Therapy ). (Tolcapone label, Contraindications)

  • TrifluoperazineantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • Verapamilcalcium channel blockerMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • Voriconazoleazole antifungalMajor

    Concomitant use of strong CYP3A4 inhibitors (e.g., azole antimycotics, HIV protease inhibitors) with CYCLOSET should be avoided. (Bromocriptine label, Drug interactions)

  • ZiprasidoneantipsychoticMajor

    The concomitant use of CYCLOSET and dopamine receptor antagonists, including neuroleptic drugs, is not recommended. (Bromocriptine label, Warnings and precautions)

  • ZolmitriptantriptanMajor

    …bowel disease [see Warnings and Precautions ( 5.5 ) ] Uncontrolled hypertension [see Warnings and Precautions ( 5.8 ) ] Recent use (i.e., within 24 hours) of another 5-HT 1 agonist, ergotamine-containing medication, or ergot-type medication (such as dihydroergotamine or methysergide) [see Drug Interactions ( 7.1 , 7.3 ) ] Concurrent administration of a monoamine… (Zolmitriptan label, Contraindications)

Moderate interactions (157)

  • Acebutololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Acetazolamidecarbonic anhydrase inhibitorModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • AliskirenantihypertensiveModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • AmantadineanticholinergicModerate

    Impulse Control/Compulsive Behaviors There have been reports of patients experiencing intense urges to gamble, increased sexual urges, intense urges to spend money uncontrollably, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, including bromocriptine, that increase central dopaminergic tone. (Bromocriptine label, Warnings and precautions)

  • Amiloridepotassium-sparing diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Amlodipinedihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Amlodipine and atorvastatindihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Amlodipine and benazeprildihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Amlodipine and olmesartandihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Amlodipine and valsartandihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • ArmodafinilCNS stimulantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • AspirinNSAIDModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Aspirin and dipyridamoleantiplatelet agentModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Atenololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Atenolol and chlorthalidonebeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Azilsartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • BalsalazidesalicylateModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • BenazeprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Betaxololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Bismuth subsalicylatesalicylateModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Bisoprololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • BosentanCYP3A4 inducerModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Brinzolamidecarbonic anhydrase inhibitorModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • BupropionantidepressantModerate

    The risk of hypertension is increased if bupropion hydrochloride extended-release tablets (XL) are used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activity [see Contraindications (4)] . (Bupropion label, Warnings and precautions)

  • Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Candesartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • CaptoprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • CarbamazepineanticonvulsantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Carbidopa and levodopadopaminergic drugModerate

    Impulse Control/Compulsive Behaviors There have been reports of patients experiencing intense urges to gamble, increased sexual urges, intense urges to spend money uncontrollably, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, including bromocriptine, that increase central dopaminergic tone. (Bromocriptine label, Warnings and precautions)

  • Carbidopa, levodopa, and entacaponedopaminergic drugModerate

    Impulse Control/Compulsive Behaviors There have been reports of patients experiencing intense urges to gamble, increased sexual urges, intense urges to spend money uncontrollably, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, including bromocriptine, that increase central dopaminergic tone. (Bromocriptine label, Warnings and precautions)

  • Carvedilolbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Chlorothiazidethiazide diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Chlorthalidonethiazide diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • ClobazambenzodiazepineModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Clonidinealpha-adrenergic agonistModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Deferasiroxiron supplementModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • DeutetrabenazineVMAT2 inhibitorModerate

    Neuroleptic Malignant Syndrome (NMS) A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with drugs that reduce dopaminergic transmission. (Deutetrabenazine label, Warnings and precautions)

  • DexamethasonecorticosteroidModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Dichlorphenamidecarbonic anhydrase inhibitorModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • DiflunisalNSAIDModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Dihydroergotamineergot alkaloidModerate

    Rarely, prolonged daily use of other ergot alkaloid drugs has been associated with cardiac valvular fibrosis. (Dihydroergotamine label, Warnings)

  • Dorzolamidecarbonic anhydrase inhibitorModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Dorzolamide and timololcarbonic anhydrase inhibitorModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Doxazosinalpha blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • EnalaprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • EnalaprilatACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Eplerenonealdosterone antagonistModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • EslicarbazepineanticonvulsantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Ethacrynic acidloop diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • EtravirineantiretroviralModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Felodipinedihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • FosinoprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • FosphenytoinanticonvulsantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Furosemideloop diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • GriseofulvinantifungalModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Guanfacinealpha-adrenergic agonistModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • HydralazinevasodilatorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Hydrochlorothiazidethiazide diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Indapamidethiazide diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Irbesartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Isradipinedihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Labetalolbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • LanreotideModerate

    Bromocriptine : Lanreotide Injection may increase the absorption of bromocriptine. (Lanreotide label, Drug interactions)

  • Levodopadopaminergic drugModerate

    Impulse Control/Compulsive Behaviors There have been reports of patients experiencing intense urges to gamble, increased sexual urges, intense urges to spend money uncontrollably, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, including bromocriptine, that increase central dopaminergic tone. (Bromocriptine label, Warnings and precautions)

  • Lidocainelocal anestheticModerate

    Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents. (Lidocaine label, Drug interactions)

  • LinezolidantibioticModerate

    …hypertension, pheochromocytoma, thyrotoxicosis and/or patients taking any of the following types of medications: directly and indirectly acting sympathomimetic agents (e.g., pseudoephedrine), vasopressive agents (e.g., epinephrine, norepinephrine), dopaminergic agents (e.g., dopamine, dobutamine) [ see Drug Interactions (7) and Clinical Pharmacology (12.3) ]. (Linezolid label, Warnings and precautions)

  • LisinoprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Lofexidinealpha-adrenergic agonistModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • LorlatinibCYP3A4 inducerModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Losartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • MecamylamineantihypertensiveModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • MesalaminesalicylateModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Methazolamidecarbonic anhydrase inhibitorModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • MethyldopaantihypertensiveModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Methylergonovineergot alkaloidModerate

    Caution should be exercised when methylergonovine maleate is used concurrently with other vasoconstrictors, ergot alkaloids, or prostaglandins. (Methylergonovine label, Drug interactions)

  • Metolazonethiazide diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Metoprololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • MinoxidilvasodilatorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • MitapivatCYP3A4 inducerModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • MitotaneCYP3A4 inducerModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • ModafinilCNS stimulantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • MoexiprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Nadololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Nafcillinpenicillin antibioticModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Naltrexone and bupropionopioid antagonistModerate

    Dopaminergic Drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with CONTRAVE. (Naltrexone and bupropion label, Drug interactions)

  • Nebivololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • NevirapineantiretroviralModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Nicardipinedihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Nifedipinedihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Nisoldipinedihydropyridine calcium channel blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • NitroprussidevasodilatorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • OctreotideModerate

    Bromocriptine: dose adjustment of bromocriptine may be necessary (‎ 7 ). (Octreotide label, Drug interactions)

  • Olmesartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • OxcarbazepineanticonvulsantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • PasireotideModerate

    Bromocriptine: Consider bromocriptine dose reduction. (Pasireotide label, Drug interactions)

  • PerindoprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • PhenobarbitalbarbiturateModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Phenoxybenzaminealpha blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Phentermine and topiramateCNS stimulantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • PhenylephrinedecongestantModerate

    Agonistic Effects (increase in BIORPHEN blood pressure effect) can occur with monoamine oxidase inhibitors (MAOI), oxytocin and oxytocic drugs, tricyclic antidepressants, angiotensin and aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot alkaloids. (Phenylephrine label, Drug interactions)

  • PhenytoinanticonvulsantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Pindololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Prazosinalpha blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • PrimaquineantimalarialModerate

    CYP3A4 Substrates Refer to the Prescribing Information for a CYP3A substrate where minimal concentration changes may lead to serious adverse reactions (e.g. rivaroxaban, calcineurin inhibitors, ergot derivatives, tyrosine kinase inhibitors) for the recommended dosage modification and/or monitoring. (Primaquine label, Drug interactions)

  • PrimidoneanticonvulsantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • ProbenecidModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Propranololbeta blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • QuinaprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • RamiprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • RasagilineMAO inhibitorModerate

    For this reason, prescribers should monitor patients for drowsiness or sleepiness, because some of the events occur well after initiation of treatment with dopaminergic medication. (Rasagiline label, Warnings and precautions)

  • RifabutinantibioticModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • RifampinantibioticModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • RifapentineantibioticModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Sacubitril and valsartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • SalsalateNSAIDModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • SelegilineMAO inhibitorModerate

    Dyskinesia ZELAPAR may potentiate dopaminergic side effects of levodopa and may cause dyskinesia or exacerbate preexisting dyskinesia. (Selegiline label, Warnings and precautions)

  • Silver sulfadiazinesulfonamideModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • SirolimusimmunosuppressantModerate

    • Drugs that could increase sirolimus blood concentrations: Bromocriptine, cimetidine, cisapride, clotrimazole, danazol, diltiazem, fluconazole, letermovir, protease inhibitors (e.g., HIV and hepatitis C that include drugs such as ritonavir, indinavir, boceprevir, and telaprevir), metoclopramide, nicardipine, troleandomycin, verapamil • Drugs and other agents… (Sirolimus label, Drug interactions)

  • SolriamfetolCNS stimulantModerate

    Drugs that Increase Blood Pressure and/or Heart Rate and Dopaminergic Drugs : Use caution when co-administering with SUNOSI. (Solriamfetol label, Drug interactions)

  • Spironolactonealdosterone antagonistModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • SulfadiazinesulfonamideModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • SulfasalazinesulfonamideModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • SuzetrigineCYP3A4 inducerModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Telmisartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Telmisartan and amlodipineangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Terazosinalpha blockerModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • TetrabenazineVMAT2 inhibitorModerate

    Neuroleptic Malignant Syndrome (NMS) A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with tetrabenazine tablets and other drugs that reduce dopaminergic transmission [see Drug Interactions (7.6) ]. (Tetrabenazine label, Warnings and precautions)

  • Tizanidinemuscle relaxantModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • TopiramateanticonvulsantModerate

    Therefore, potent inhibitors or inducers of CYP3A4 may increase or reduce the circulating levels of CYCLOSET, respectively. (Bromocriptine label, Drug interactions)

  • Torsemideloop diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • TrandolaprilACE inhibitorModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Triamterenepotassium-sparing diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • ValbenazineVMAT2 inhibitorModerate

    Neuroleptic Malignant Syndrome (NMS ) A potentially fatal symptom complex referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with drugs that reduce dopaminergic transmission. (Valbenazine label, Warnings and precautions)

  • Valsartanangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Use caution in patients taking antihypertensive medications. (Bromocriptine label, Warnings and precautions)

  • ZonisamideanticonvulsantModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

Minor mentions (40)

  • Albuterolbeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • AmphetamineCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Arformoterolbeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Articaine and epinephrinelocal anestheticMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • BenzphetamineCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Ergot derivatives: dihydroergotamine ergotamine methylergonovine ↑ dihydroergotamine ↑ ergotamine ↑ methylergonovine Concomitant administration with dihydroergotamine, ergotamine or methylergonovine is not recommended. (Bictegravir, emtricitabine, and tenofovir alafenamide label, Drug interactions)

  • There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Budesonide and formoterolcorticosteroidMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Falling Asleep During Activities of Daily Living and Somnolence Patients taking carbidopa-levodopa products alone or with other dopaminergic drugs have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living (includes operation of motor vehicles). (Carbidopa label, Warnings)

  • DexmethylphenidateCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • DextroamphetamineCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • DiethylpropionCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • DobutaminesympathomimeticMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • DroxidopasympathomimeticMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • EphedrinesympathomimeticMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • EpinephrinesympathomimeticMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Ergotamine and caffeineergot alkaloidMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Fluticasone and salmeterolcorticosteroidMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Formoterolbeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Ipratropium and albuterolanticholinergicMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Isoproterenolbeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Levalbuterolbeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • LisdexamfetamineCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • MethamphetamineCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • MethylphenidateCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Midodrinealpha-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • OxymetazolinedecongestantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • PhendimetrazineCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • PhentermineCNS stimulantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Pramipexoledopamine agonistMinor

    The expected incidence of these events, however, is so low that even if pramipexole caused these events at rates similar to those attributable to other dopaminergic therapies, it would be unlikely that even a single case would have occurred in a cohort of the size exposed to pramipexole in studies to date. (Pramipexole label, Warnings and precautions)

  • Prilocaine and epinephrinelocal anestheticMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • PseudoephedrinedecongestantMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Ropiniroledopamine agonistMinor

    Fibrotic Complications Cases of retroperitoneal fibrosis, pulmonary infiltrates, pleural effusion, pleural thickening, pericarditis, and cardiac valvulopathy have been reported in some patients treated with ergot-derived dopaminergic agents. (Ropinirole label, Warnings and precautions)

  • Salmeterolbeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Terbutalinebeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Umeclidinium and vilanterolanticholinergicMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Vibegronbeta-adrenergic agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

Check Bromocriptine against everything you take. Add your full list; every pair is checked at once.

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.