Interaction Checker

Carboplatin interactions

Carboplatin (Paraplatin) has 11 documented interactions across the FDA labels and fact sheets we index: 7 major, 3 moderate, 0 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (7)

  • AmikacinaminoglycosideMajor

    Aminoglycosides : Avoid concomitant use with aminoglycosides. (Carboplatin label, Drug interactions)

  • GentamicinaminoglycosideMajor

    Aminoglycosides : Avoid concomitant use with aminoglycosides. (Carboplatin label, Drug interactions)

  • NeomycinaminoglycosideMajor

    Aminoglycosides : Avoid concomitant use with aminoglycosides. (Carboplatin label, Drug interactions)

  • PhenytoinanticonvulsantMajor

    …hydroxide, magnesium hydroxide Prevention or Management: Phenytoin and antacids should not be taken at the same time of day Antineoplastic agents (usually in combination) Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam,… (Phenytoin label, Drug interactions)

  • PlazomicinaminoglycosideMajor

    Aminoglycosides : Avoid concomitant use with aminoglycosides. (Carboplatin label, Drug interactions)

  • SorafenibMajor

    • NEXAVAR in combination with carboplatin and paclitaxel is contraindicated in patients with squamous cell lung cancer [see Warnings and Precautions ( 5.8 )] . (Sorafenib label, Contraindications)

  • TobramycinaminoglycosideMajor

    Aminoglycosides : Avoid concomitant use with aminoglycosides. (Carboplatin label, Drug interactions)

Moderate interactions (3)

  • FosphenytoinanticonvulsantModerate

    …methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin Drugs that may decrease phenytoin serum levels Antineoplastic agents usually in combination Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam,… (Fosphenytoin label, Drug interactions)

  • PaclitaxelModerate

    …patients with NSCLC, resume treatment if recommended at permanently reduced doses for both weekly protein-bound paclitaxel for Injectable Suspension (albumin-bound) and every-3-week carboplatin after ANC recovers to at least 1,500 cells/mm 3 and platelet count of at least 100,000 cells/mm 3 on Day 1 or to an ANC of at least 500 cells/mm 3 and platelet count of… (Paclitaxel label, Warnings and precautions)

  • TrastuzumabModerate

    In BCIRG006, a total of 2.9% (31/1056) of patients in the TCH (docetaxel, carboplatin, trastuzumab) arm (1.5% during the chemotherapy phase and 1.4% during the monotherapy phase) and 5.7% (61/1068) of patients in the AC-TH arm (1.5% during the chemotherapy phase and 4.2% during the monotherapy phase) discontinued trastuzumab due to cardiac toxicity. (Trastuzumab label, Warnings and precautions)

No significant interaction reported (1)

  • BevacizumabNo interaction

    Effects of VEGZELMA on Other Drugs No clinically meaningful effect on the pharmacokinetics of irinotecan or its active metabolite SN38, interferon alfa, carboplatin or paclitaxel was observed when bevacizumab was administered in combination with these drugs; however, 3 of the 8 patients receiving bevacizumab with paclitaxel and carboplatin had lower paclitaxel… (Bevacizumab label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.