Dicloxacillin interactions

Dicloxacillin (Dynapen), a penicillin antibiotic has 80 documented interactions across the FDA labels and fact sheets we index: 22 major, 52 moderate, 6 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (22)

  • AmikacinaminoglycosideMajor

    In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)

  • Amoxicillinpenicillin antibioticMajor

    AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AUGMENTIN or to other beta‑lactams (e.g., penicillins or cephalosporins). (Amoxicillin and clavulanate label, Contraindications)

  • Ampicillinpenicillin antibioticMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • Ampicillin and sulbactampenicillin antibioticMajor

    CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Ampicillin and sulbactam label, Contraindications)

  • Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (Dicloxacillin label, Drug interactions)

  • CefazolincephalosporinMajor

    Hypersensitivity to cefazolin or other cephalosporin class antibacterial drugs, penicillins, or other beta-lactams (4.1) (Cefazolin label, Contraindications)

  • CefepimecephalosporinMajor

    Patients with known immediate hypersensitivity reactions to cefepime or other cephalosporins, penicillins or other beta-lactam antibacterial drugs. (Cefepime label, Contraindications)

  • CefoxitincephalosporinMajor

    Hypersensitivity to cefoxitin or other beta-lactam antibacterial drugs. (Cefoxitin label, Contraindications)

  • CeftarolinecephalosporinMajor

    Hypersensitivity Reactions Serious and occasionally fatal hypersensitivity (anaphylactic) reactions and serious skin reactions have been reported in patients receiving beta-lactam antibacterial drugs. (Ceftaroline label, Warnings and precautions)

  • CeftriaxonecephalosporinMajor

    Anaphylaxis to ceftriaxone or other cephalosporin class antibacterials, penicillins, or other beta-lactam antibacterials ( 4.1 ) (Ceftriaxone label, Contraindications)

  • CefuroximecephalosporinMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Demeclocyclinetetracycline antibioticMajor

    Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (Demeclocycline label, Drug interactions)

  • Doxycyclinetetracycline antibioticMajor

    Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)

  • ErtapenemantibioticMajor

    INVANZ is contraindicated in patients with known hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams. (Ertapenem label, Contraindications)

  • GentamicinaminoglycosideMajor

    In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)

  • Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (Imipenem and cilastatin label, Warnings and precautions)

  • Minocyclinetetracycline antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • NeomycinaminoglycosideMajor

    In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)

  • PlazomicinaminoglycosideMajor

    In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)

  • Tetracyclinetetracycline antibioticMajor

    Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (Dicloxacillin label, Drug interactions)

  • TobramycinaminoglycosideMajor

    In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)

Moderate interactions (52)

  • ApixabananticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • ArgatrobananticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • AztreonamantibioticModerate

    Use caution when CAYSTON is administered to patients with a known allergic reaction to beta-lactams. (Aztreonam label, Warnings and precautions)

  • Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Benazepril and hydrochlorothiazide label, Warnings)

  • Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Bisoprolol and hydrochlorothiazide label, Warnings)

  • BivalirudinanticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Candesartan and hydrochlorothiazide label, Warnings)

  • CefaclorcephalosporinModerate

    IF THIS PRODUCT IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-SENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Cefaclor label, Warnings)

  • CefadroxilcephalosporinModerate

    Warnings and Precautions BEFORE THERAPY WITH CEFADROXIL IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFADROXIL, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. (Cefadroxil label, Warnings and precautions)

  • CefdinircephalosporinModerate

    IF CEFDINIR IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-HYPERSENSITIVITY AMONG β-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Cefdinir label, Warnings)

  • CefiximecephalosporinModerate

    If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)

  • CefotaximecephalosporinModerate

    THIS PRODUCT SHOULD BE GIVEN WITH CAUTION TO PATIENTS WITH TYPE I HYPERSENSITIVITY REACTIONS TO PENICILLIN. (Cefotaxime label, Warnings)

  • CefotetancephalosporinModerate

    IF THIS PRODUCT IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-HYPERSENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Cefotetan label, Warnings)

  • CefpodoximecephalosporinModerate

    IF CEFPODOXIME IS TO BE ADMINISTERED TO PENICILLIN SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS HYPERSENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Cefpodoxime label, Warnings)

  • CefprozilcephalosporinModerate

    IF THIS PRODUCT IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-SENSITIVITY AMONG β-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Cefprozil label, Warnings)

  • CeftazidimecephalosporinModerate

    IF THIS PRODUCT IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS- HYPERSENSITIVITY AMONG BETA-LACTAM ANTIBACTERIAL DRUGS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Ceftazidime label, Warnings)

  • CephalexincephalosporinModerate

    • Serious hypersensitivity (anaphylactic) reactions: Prior to use, inquire regarding history of hypersensitivity to beta-lactam antibacterial drugs. (Cephalexin label, Warnings and precautions)

  • Cholestyraminebile acid sequestrantModerate

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)

  • Colestipolbile acid sequestrantModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • DabigatrananticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • Dichlorphenamidecarbonic anhydrase inhibitorModerate

    Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia (e.g., loop diuretics, thiazide diuretics, laxatives, antifungals, penicillins, and theophylline) [see Warnings and Precautions (5.3) ] . (Dichlorphenamide label, Drug interactions)

  • EdoxabananticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Enalapril and hydrochlorothiazide label, Warnings)

  • EnoxaparinanticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • FondaparinuxanticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • HeparinanticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • Hydrochlorothiazidethiazide diureticModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Hydrochlorothiazide label, Warnings and precautions)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Irbesartan and hydrochlorothiazide label, Warnings and precautions)

  • LeflunomideimmunosuppressantModerate

    In patients taking ARAVA, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Leflunomide label, Drug interactions)

  • Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Lisinopril and hydrochlorothiazide label, Warnings)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Losartan and hydrochlorothiazide label, Warnings and precautions)

  • MethotrexateimmunosuppressantModerate

    Effect of Other Drugs on XATMEP Oral Antibiotics Penicillins may reduce the renal clearance of methotrexate; increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with methotrexate. (Methotrexate label, Drug interactions)

  • Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Metoprolol and hydrochlorothiazide label, Warnings and precautions)

  • MycophenolateimmunosuppressantModerate

    Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing mycophenolate… (Mycophenolate label, Drug interactions)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Olmesartan and hydrochlorothiazide label, Warnings and precautions)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Olmesartan, amlodipine, and hydrochlorothiazide label, Warnings and precautions)

  • Penicillin Gpenicillin antibioticModerate

    Other drugs may compete with penicillin G for renal tubular secretion and thus prolong the serum half-life of penicillin. (Penicillin G label, Drug interactions)

  • Piperacillin and tazobactampenicillin antibioticModerate

    Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients. (Piperacillin and tazobactam label, Warnings and precautions)

  • ProbenecidModerate

    Probenecid administered concomitantly with penicillins increases and prolongs serum penicillin levels (see DOSAGE AND ADMINISTRATION ). (Dicloxacillin label, Drug interactions)

  • Probenecid administered concomitantly with penicillins increases and prolongs serum penicillin levels (see DOSAGE AND ADMINISTRATION ). (Dicloxacillin label, Drug interactions)

  • ProtamineModerate

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (Protamine label, Precautions)

  • Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Quinapril and hydrochlorothiazide label, Warnings)

  • RivaroxabananticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

  • SalsalateNSAIDModerate

    Salicylate competes with a number of drugs for protein binding sites, notably penicillin, thiopental, thyroxine, triiodothyronine, phenytoin, sulfinpyrazone, naproxen, warfarin, methotrexate, and possibly corticosteroids. [When Salsalate tablets, USP are administered with aspirin, its protein binding is reduced, although the clearance of free Salsalate tablets,… (Salsalate label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Spironolactone and hydrochlorothiazide label, Warnings)

  • Succinylcholineneuromuscular blockerModerate

    Drugs that May Enhance the Neuromuscular Blocking Action of Succinylcholine : promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, terbutaline, and drugs that reduce plasma cholinesterase… (Succinylcholine label, Drug interactions)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Telmisartan and hydrochlorothiazide label, Warnings and precautions)

  • TeriflunomideimmunosuppressantModerate

    In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Teriflunomide label, Drug interactions)

  • Triamterenepotassium-sparing diureticModerate

    …from blood bank (may contain up to 30 mEq of potassium per liter of plasma or up to 65 mEq per liter of whole blood when stored for more than 10 days); low-salt milk (may contain up to 60 mEq of potassium per liter); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium). (Triamterene label, Drug interactions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Triamterene and hydrochlorothiazide label, Warnings)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Valsartan and hydrochlorothiazide label, Warnings and precautions)

  • WarfarinanticoagulantModerate

    Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)

Minor mentions (6)

  • Erythromycinmacrolide antibioticMinor

    Infants born to women treated during pregnancy with oral erythromycin for early syphilis should be treated with an appropriate penicillin regimen. (Erythromycin label, Warnings)

  • LinezolidantibioticMinor

    …Catheter-Related Bloodstream Infections, Including Those With Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI… (Linezolid label, Warnings and precautions)

  • MeropenemantibioticMinor

    There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe hypersensitivity reactions when treated with another β-lactam. (Meropenem label, Warnings and precautions)

  • Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (Sodium phenylacetate and sodium benzoate label, Drug interactions)

  • Tigecyclinetetracycline antibioticMinor

    Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (Dicloxacillin label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.