Dicloxacillin interactions
Dicloxacillin (Dynapen), a penicillin antibiotic has 39 documented interactions across the FDA labels and fact sheets we index: 10 major, 27 moderate, 2 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.
Major interactions (10)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AUGMENTIN or to other beta‑lactams (e.g., penicillins or cephalosporins). (Amoxicillin and clavulanate label, Contraindications)
- Ampicillinpenicillin antibioticMajor
CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
- GentamicinaminoglycosideMajor
In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)
Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)
- NeomycinaminoglycosideMajor
In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)
- Tetracyclinetetracycline antibioticMajor
Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. (Dicloxacillin label, Drug interactions)
- TobramycinaminoglycosideMajor
In vitro mixing of penicillins and aminoglycosides should be avoided during concomitant therapy and the drugs should be administered separately. (Dicloxacillin label, Drug interactions)
Moderate interactions (27)
- ApixabananticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
- Bisoprolol and hydrochlorothiazidebeta blockerModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Bisoprolol and hydrochlorothiazide label, Warnings)
- CefadroxilcephalosporinModerate
Warnings and Precautions BEFORE THERAPY WITH CEFADROXIL IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFADROXIL, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. (Cefadroxil label, Warnings and precautions)
- CefdinircephalosporinModerate
IF CEFDINIR IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-HYPERSENSITIVITY AMONG β-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Cefdinir label, Warnings)
- CefiximecephalosporinModerate
If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)
- CefpodoximecephalosporinModerate
IF CEFPODOXIME IS TO BE ADMINISTERED TO PENICILLIN SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS HYPERSENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. (Cefpodoxime label, Warnings)
- CephalexincephalosporinModerate
• Serious hypersensitivity (anaphylactic) reactions: Prior to use, inquire regarding history of hypersensitivity to beta-lactam antibacterial drugs. (Cephalexin label, Warnings and precautions)
- Cholestyraminebile acid sequestrantModerate
Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)
- DabigatrananticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
- EdoxabananticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
- EnoxaparinanticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
- FondaparinuxanticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
- HeparinanticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
- Hydrochlorothiazidethiazide diureticModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Hydrochlorothiazide label, Warnings and precautions)
- LeflunomideimmunosuppressantModerate
In patients taking ARAVA, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Leflunomide label, Drug interactions)
- Lisinopril and hydrochlorothiazideACE inhibitorModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Lisinopril and hydrochlorothiazide label, Warnings)
- Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Losartan and hydrochlorothiazide label, Warnings and precautions)
- MethotrexateimmunosuppressantModerate
Effect of Other Drugs on XATMEP Oral Antibiotics Penicillins may reduce the renal clearance of methotrexate; increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with methotrexate. (Methotrexate label, Drug interactions)
- MycophenolateimmunosuppressantModerate
Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing MYHIBBIN… (Mycophenolate label, Drug interactions)
- Penicillin Gpenicillin antibioticModerate
Other drugs may compete with penicillin G for renal tubular secretion and thus prolong the serum half-life of penicillin. (Penicillin G label, Drug interactions)
- RivaroxabananticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
- Spironolactone and hydrochlorothiazidealdosterone antagonistModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Spironolactone and hydrochlorothiazide label, Warnings)
- TeriflunomideimmunosuppressantModerate
In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Teriflunomide label, Drug interactions)
- Triamterenepotassium-sparing diureticModerate
…from blood bank (may contain up to 30 mEq of potassium per liter of plasma or up to 65 mEq per liter of whole blood when stored for more than 10 days); low-salt milk (may contain up to 60 mEq of potassium per liter); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium). (Triamterene label, Drug interactions)
- Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Triamterene and hydrochlorothiazide label, Warnings)
- Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Valsartan and hydrochlorothiazide label, Warnings and precautions)
- WarfarinanticoagulantModerate
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (Dicloxacillin label, Drug interactions)
Minor mentions (2)
- Erythromycinmacrolide antibioticMinor
Infants born to women treated during pregnancy with oral erythromycin for early syphilis should be treated with an appropriate penicillin regimen. (Erythromycin label, Warnings)
- LinezolidantibioticMinor
…Catheter-Related Bloodstream Infections, Including Those With Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI… (Linezolid label, Warnings and precautions)
Check Dicloxacillin against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.