Interaction Checker

Latanoprost interactions

Latanoprost (Xalatan), a prostaglandin analog has 18 documented interactions across the FDA labels and fact sheets we index: 6 major, 11 moderate, 1 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (6)

  • AspirinNSAIDMajor

    The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (Latanoprost label, Drug interactions)

  • Aspirin and dipyridamoleantiplatelet agentMajor

    The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (Latanoprost label, Drug interactions)

  • Bimatoprostprostaglandin analogMajor

    The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (Latanoprost label, Drug interactions)

  • KetorolacNSAIDMajor

    Ketorolac tromethamine is contraindicated in labor and delivery because, through its prostaglandin synthesis inhibitory effect, it may adversely affect fetal circulation and inhibit uterine contractions, thus increasing the risk of uterine hemorrhage. (Ketorolac label, Contraindications)

  • Misoprostolprostaglandin analogMajor

    The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (Latanoprost label, Drug interactions)

  • Treprostinilprostaglandin analogMajor

    The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (Latanoprost label, Drug interactions)

Moderate interactions (11)

  • Atenololbeta blockerModerate

    Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. (Atenolol label, Drug interactions)

  • CelecoxibNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Celecoxib label, Warnings and precautions)

  • DiclofenacNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Diclofenac label, Warnings and precautions)

  • EtodolacNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Etodolac label, Warnings)

  • Furosemideloop diureticModerate

    Indomethacin Coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis. (Furosemide label, Drug interactions)

  • IbuprofenNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Ibuprofen label, Warnings and precautions)

  • IndomethacinNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Indomethacin label, Warnings and precautions)

  • MeloxicamNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Meloxicam label, Warnings and precautions)

  • NabumetoneNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Nabumetone label, Warnings)

  • NaproxenNSAIDModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Naproxen label, Warnings and precautions)

  • Sumatriptan and naproxentriptanModerate

    Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (Sumatriptan and naproxen label, Warnings and precautions)

Minor mentions (1)

  • Potassium chloridepotassium supplementMinor

    Nonsteroidal Anti-inflammatory Drugs (NSAIDs) NSAIDs may produce potassium retention by reducing renal synthesis of prostaglandin E and impairing the renin-angiotensin system. (Potassium chloride label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.