Interaction Checker

Melphalan interactions

Melphalan (Alkeran, Evomela) has 51 documented interactions across the FDA labels and fact sheets we index: 1 major, 2 moderate, 47 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (1)

  • AzathioprineimmunosuppressantMajor

    Patients with rheumatoid arthritis previously treated with alkylating agents (cyclophosphamide, chlorambucil, melphalan, or others) may have a prohibitive risk of malignancy if treated with IMURAN. (Azathioprine label, Contraindications)

Moderate interactions (2)

  • CyclosporineimmunosuppressantModerate

    Drug Interactions The development of severe renal failure has been reported in patients treated with a single dose of intravenous melphalan followed by standard oral doses of cyclosporine. (Melphalan label, Drug interactions)

  • LenalidomideModerate

    An increase in hematologic SPM including AML and MDS occurred in 5.3% of patients with NDMM receiving REVLIMID in combination with oral melphalan compared with 1.3% of patients receiving melphalan without REVLIMID. (Lenalidomide label, Warnings and precautions)

Minor mentions (47)

  • AzelastineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Azelastine and fluticasoneantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • BeclomethasonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • BetamethasonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Brompheniramine, pseudoephedrine, and dextromethorphanantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • BudesonidecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Budesonide and formoterolcorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • CarbinoxamineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • CetirizineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • ChlorpheniramineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • CiclesonidecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • CisplatinMinor

    Cisplatin may affect melphalan kinetics by inducing renal dysfunction and subsequently altering melphalan clearance. (Melphalan label, Drug interactions)

  • ClemastineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • ClobetasolcorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • CyproheptadineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DeflazacortcorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DesloratadineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DesonidecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DexamethasonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DexchlorpheniramineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DimenhydrinateantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DiphenhydramineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • DoxylamineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Doxylamine and pyridoxineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • FexofenadineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • FludrocortisonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • FlunisolidecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • FluocinonidecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • FluticasonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Fluticasone and salmeterolcorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • HalobetasolcorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Hydrocodone and chlorpheniramineopioidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • HydrocortisonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • HydroxyzineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • LevocetirizineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • LoratadineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • MeclizineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • MethylprednisolonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • MometasonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • OlopatadineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Olopatadine and mometasoneantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • PrednisolonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • PrednisonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • PromethazineantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Promethazine and codeineopioidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • Promethazine and dextromethorphanantihistamineMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

  • TriamcinolonecorticosteroidMinor

    The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (Melphalan label, Warnings)

No significant interaction reported (1)

  • BortezomibNo interaction

    Drugs Without Clinically Significant Interactions with Bortezomib No clinically significant drug interactions have been observed when bortezomib was coadministered with dexamethasone, omeprazole, or melphalan in combination with prednisone [see Clinical Pharmacology (12.3) ] . (Bortezomib label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.