Interaction Checker

Memantine interactions

Memantine (Namenda) has 15 documented interactions across the FDA labels and fact sheets we index: 0 major, 6 moderate, 9 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Moderate interactions (6)

  • AmantadineanticholinergicModerate

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (Memantine label, Drug interactions)

  • Brompheniramine, pseudoephedrine, and dextromethorphanantihistamineModerate

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (Memantine label, Drug interactions)

  • Dextromethorphanserotonergic drugModerate

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (Memantine label, Drug interactions)

  • Dextromethorphan and quinidineserotonergic drugModerate

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (Memantine label, Drug interactions)

  • KetamineCNS depressantModerate

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (Memantine label, Drug interactions)

  • Promethazine and dextromethorphanantihistamineModerate

    Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution. (Memantine label, Drug interactions)

Minor mentions (9)

  • Acetazolamidecarbonic anhydrase inhibitorMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • Brinzolamidecarbonic anhydrase inhibitorMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • Dichlorphenamidecarbonic anhydrase inhibitorMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • Dorzolamidecarbonic anhydrase inhibitorMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • Dorzolamide and timololcarbonic anhydrase inhibitorMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • Methazolamidecarbonic anhydrase inhibitorMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • Omeprazole and sodium bicarbonateproton pump inhibitorMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • Sodium bicarbonateantacidMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

  • ZonisamideanticonvulsantMinor

    Urine pH is altered by diet, drugs (e.g. carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g. renal tubular acidosis or severe infections of the urinary tract). (Memantine label, Drug interactions)

Check Memantine against everything you take. Add your full list; every pair is checked at once.

Open in the checker

Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.