Methyltestosterone interactions

Methyltestosterone (Methitest, Android), an androgen has 95 documented interactions across the FDA labels and fact sheets we index: 4 major, 57 moderate, 34 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (4)

  • CONTRAINDICATIONS: Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. (Chorionic gonadotropin label, Contraindications)

  • DoravirineantiretroviralMajor

    These drugs include, but are not limited to, the following: the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital, phenytoin the androgen receptor inhibitor enzalutamide the antimycobacterials rifampin, rifapentine the cytotoxic agent mitotane St. (Doravirine label, Contraindications)

  • Finasteride5-alpha reductase inhibitorMajor

    Because of the ability of Type II 5α-reductase inhibitors to inhibit the conversion of testosterone to 5α-dihydrotestosterone (DHT), finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant female who receives finasteride. (Finasteride label, Contraindications)

  • TestosteroneandrogenMajor

    To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use. (Methyltestosterone label, Warnings)

Moderate interactions (57)

  • ApixabananticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • ArgatrobananticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • Azelastine and fluticasoneantihistamineModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • BeclomethasonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • BetamethasonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • BivalirudinanticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • BudesonidecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • Budesonide and formoterolcorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • PRECAUTIONS General Induction of androgen secretion by hCG may cause fluid retention. (Choriogonadotropin alfa label, Precautions)

  • CiclesonidecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • ClobetasolcorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • Conjugated estrogensestrogenModerate

    Free hormone concentrations, such as testosterone and estradiol, may be decreased. (Conjugated estrogens label, Precautions)

  • Free hormone concentrations, such as testosterone and estradiol, may be decreased. (Conjugated estrogens and bazedoxifene label, Warnings and precautions)

  • DabigatrananticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • DeflazacortcorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • DesonidecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • DexamethasonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • EdoxabananticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • EnoxaparinanticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • Free hormone concentrations, such as testosterone and estradiol, may be decreased. (Estradiol and norethindrone label, Warnings and precautions)

  • FludrocortisonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • FlunisolidecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • FluocinonidecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • FluticasonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • Fluticasone and salmeterolcorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • FollitropinModerate

    For Men : Clinical monitoring for spermatogenesis utilizes the following indirect or direct measures: Serum testosterone level Semen analysis 5.11 FOLLISTIM Pen The FOLLISTIM Pen is intended only for use with FOLLISTIM AQ Cartridge. (Follitropin label, Warnings and precautions)

  • FondaparinuxanticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • GlimepiridesulfonylureaModerate

    …medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (Glimepiride label, Drug interactions)

  • GoserelinModerate

    Effect on QT/QTc Interval: Androgen deprivation therapy may prolong the QT interval. (Goserelin label, Warnings and precautions)

  • HalobetasolcorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • HeparinanticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • HydrocortisonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • Insulin aspartinsulinModerate

    Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (Methyltestosterone label, Drug interactions)

  • Insulin degludecinsulinModerate

    Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (Methyltestosterone label, Drug interactions)

  • Insulin detemirinsulinModerate

    Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (Methyltestosterone label, Drug interactions)

  • Insulin glargineinsulinModerate

    Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (Methyltestosterone label, Drug interactions)

  • Insulin lisproinsulinModerate

    Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (Methyltestosterone label, Drug interactions)

  • Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (Methyltestosterone label, Drug interactions)

  • LeuprolideModerate

    Tumor Flare: Increased serum testosterone (~ 50% above baseline) may occur when initiating treatment with LUPRON DEPOT. (Leuprolide label, Warnings and precautions)

  • Levothyroxinethyroid hormoneModerate

    Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nictonic Acid These drugs may decrease serum TBG concentration. (Levothyroxine label, Drug interactions)

  • Liothyroninethyroid hormoneModerate

    Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nicotinic Acid These drugs may decrease serum TBG concentration. (Liothyronine label, Drug interactions)

  • LovastatinstatinModerate

    However, clinical studies have shown that lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration. (Lovastatin label, Drug interactions)

  • MedroxyprogesteroneprogestinModerate

    The following laboratory tests may be affected by progestins including MPA Injectable Suspension, USP: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol). (Medroxyprogesterone label, Drug interactions)

  • MethylprednisolonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • MometasonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • Olopatadine and mometasoneantihistamineModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • Pioglitazone and glimepiridethiazolidinedioneModerate

    …anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs… (Pioglitazone and glimepiride label, Drug interactions)

  • PrednisolonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • PrednisonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • Ramelteonsedative-hypnoticModerate

    Reproductive effects: Include decreased testosterone and increased prolactin levels. (Ramelteon label, Warnings and precautions)

  • RivaroxabananticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    Abiraterone: Spironolactone binds to the androgen receptor and may increase prostate‑specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. (Spironolactone and hydrochlorothiazide label, Drug interactions)

  • Tamoxifenselective estrogen receptor modulatorModerate

    Hypercalcemia in Patients with Metastatic Breast Cancer As with other additive hormonal therapy (estrogens and androgens), hypercalcemia has been reported in some breast cancer patients with bone metastases within a few weeks of starting treatment with tamoxifen. (Tamoxifen label, Warnings and precautions)

  • TirzepatideGLP-1 receptor agonistModerate

    Insulin: In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements. (Methyltestosterone label, Drug interactions)

  • TriamcinolonecorticosteroidModerate

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (Methyltestosterone label, Warnings)

  • TriptorelinModerate

    Tumor Flare: Transient increase in serum testosterone levels can occur within the first few weeks of treatment. (Triptorelin label, Warnings and precautions)

  • WarfarinanticoagulantModerate

    DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (Methyltestosterone label, Drug interactions)

Minor mentions (34)

  • Acetazolamidecarbonic anhydrase inhibitorMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Amiloridepotassium-sparing diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Bumetanideloop diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Chlorothiazidethiazide diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Chlorthalidonethiazide diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Eplerenonealdosterone antagonistMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Ethacrynic acidloop diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Furosemideloop diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Hydrochlorothiazidethiazide diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Indapamidethiazide diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Levothyroxine and liothyroninethyroid hormoneMinor

    Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. (Methyltestosterone label, Precautions)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Methimazoleantithyroid drugMinor

    Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. (Methyltestosterone label, Precautions)

  • Metolazonethiazide diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Propylthiouracilantithyroid drugMinor

    Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. (Methyltestosterone label, Precautions)

  • In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Spironolactonealdosterone antagonistMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Teriparatidethyroid hormoneMinor

    Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. (Methyltestosterone label, Precautions)

  • Torsemideloop diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Triamterenepotassium-sparing diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticMinor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    In addition to discontinuation of the drug, diuretic therapy may be required. (Methyltestosterone label, Warnings)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.