Minocycline interactions

Minocycline (Minocin, Solodyn), a tetracycline antibiotic has 35 documented interactions across the FDA labels and fact sheets we index: 10 major, 17 moderate, 7 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (10)

  • AdapaleneretinoidMajor

    Avoid concomitant use of isotretinoin and EMROSI because isotretinoin, a systemic retinoid, is also known to cause idiopathic intracranial hypertension. (Minocycline label, Warnings and precautions)

  • Amoxicillinpenicillin antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • Ampicillinpenicillin antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • Dicloxacillinpenicillin antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • IsotretinoinretinoidMajor

    Avoid concomitant use of isotretinoin and EMROSI because isotretinoin, a systemic retinoid, is also known to cause idiopathic intracranial hypertension. (Minocycline label, Warnings and precautions)

  • Penicillin Gpenicillin antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • Penicillin Vpenicillin antibioticMajor

    Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)

  • Tetracyclinetetracycline antibioticMajor

    EMROSI is contraindicated in patients with a history of hypersensitivity to any of the tetracyclines [see Warnings and Precautions (5.1) ]. (Minocycline label, Contraindications)

  • TretinoinretinoidMajor

    Avoid concomitant use of isotretinoin and EMROSI because isotretinoin, a systemic retinoid, is also known to cause idiopathic intracranial hypertension. (Minocycline label, Warnings and precautions)

Moderate interactions (17)

  • ApixabananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • Atovaquone and proguanilantimalarialModerate

    Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)

  • CalciumVitamin and mineralModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • Cholestyraminebile acid sequestrantModerate

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)

  • DabigatrananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • EdoxabananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • EnoxaparinanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • FondaparinuxanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • GlimepiridesulfonylureaModerate

    …antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (Glimepiride label, Drug interactions)

  • HeparinanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • IronVitamin and mineralModerate

    Iron binds these drugs in the gut and reduces their absorption; separate the doses. (NIH Office of Dietary Supplements, Iron)

  • MagnesiumVitamin and mineralModerate

    Magnesium-containing supplements and antacids reduce absorption of these drugs; separate the doses by at least two hours. (NIH Office of Dietary Supplements, Magnesium)

  • QuinaprilACE inhibitorModerate

    Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets. (Quinapril label, Drug interactions)

  • RivaroxabananticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • SucralfateModerate

    Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. (Sucralfate label, Drug interactions)

  • WarfarinanticoagulantModerate

    Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Minocycline label, Drug interactions)

  • ZincVitamin and mineralModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

Minor mentions (7)

  • Antacids and Iron Preparations Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and iron-containing preparations. (Minocycline label, Drug interactions)

  • Deferasiroxiron supplementMinor

    Antacids and Iron Preparations Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and iron-containing preparations. (Minocycline label, Drug interactions)

  • Levothyroxinethyroid hormoneMinor

    EMROSI may induce hyperpigmentation in many organs, including nails, bone, skin, eyes, thyroid, visceral tissue, oral cavity (teeth, mucosa, alveolar bone), sclerae and heart valves. (Minocycline label, Warnings and precautions)

  • Liothyroninethyroid hormoneMinor

    EMROSI may induce hyperpigmentation in many organs, including nails, bone, skin, eyes, thyroid, visceral tissue, oral cavity (teeth, mucosa, alveolar bone), sclerae and heart valves. (Minocycline label, Warnings and precautions)

  • Methimazoleantithyroid drugMinor

    EMROSI may induce hyperpigmentation in many organs, including nails, bone, skin, eyes, thyroid, visceral tissue, oral cavity (teeth, mucosa, alveolar bone), sclerae and heart valves. (Minocycline label, Warnings and precautions)

  • Propylthiouracilantithyroid drugMinor

    EMROSI may induce hyperpigmentation in many organs, including nails, bone, skin, eyes, thyroid, visceral tissue, oral cavity (teeth, mucosa, alveolar bone), sclerae and heart valves. (Minocycline label, Warnings and precautions)

  • Sodium bicarbonateantacidMinor

    Antacids and Iron Preparations Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and iron-containing preparations. (Minocycline label, Drug interactions)

No significant interaction reported (1)

  • TheophyllinemethylxanthineNo interaction

    …ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone theophylline absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin * Refer to PRECAUTIONS , Drug Interactions for information regarding table. (Theophylline label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.