Interaction Checker

Polymyxin B and trimethoprim ophthalmic interactions

Polymyxin B and trimethoprim ophthalmic (Polytrim), an antibiotic has 4 documented interactions across the FDA labels and fact sheets we index: 2 major, 2 moderate, 0 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (2)

  • GentamicinaminoglycosideMajor

    Concurrent and/or sequential systemic or topical use of other potentially neurotoxic and/or nephrotoxic drugs, such as cisplatin, cephaloridine, kanamycin, amikacin, neomycin, polymyxin B, colistin, paromomycin, streptomycin, tobramycin, vancomycin, and viomycin, should be avoided (see PRECAUTIONS, Drug Interactions section). (Gentamicin label, Boxed warning)

  • NeomycinaminoglycosideMajor

    Concurrent and/or sequential systemic, oral or topical use of other aminoglycosides, including paromomycin and other potentially nephrotoxic and/or neurotoxic drugs such as bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin, should be avoided because the toxicity may be additive. (Neomycin label, Boxed warning)

Moderate interactions (2)

  • Folic acid (folate)Vitamin and mineralModerate

    Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. (Polymyxin B and trimethoprim ophthalmic label, Precautions)

  • Sulfamethoxazole and trimethoprimsulfonamideModerate

    In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral trimethoprim and sulfamethoxazole at the time of conception or shortly thereafter. (Polymyxin B and trimethoprim ophthalmic label, Precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.