Interaction Checker

Pyrazinamide interactions

Pyrazinamide, an antibiotic has 4 documented interactions across the FDA labels and fact sheets we index: 0 major, 2 moderate, 2 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Moderate interactions (2)

  • AlcoholAlcoholModerate

    Those patients with preexisting liver disease or those at increased risk for drug related hepatitis (e.g., alcohol abusers) should be followed closely. (Pyrazinamide label, Warnings)

  • RifampinantibioticModerate

    …exposure Thiazolidinediones Rosiglitazone Decrease AUC by 66% Tricyclic Antidepressants Nortriptyline A tuberculosis treatment regimen including rifampin (600 mg/day), isoniazid (300 mg/day), pyrazinamide (500 mg 3× per day), and pyridoxine (25 mg) was associated with higher than expected doses of nortriptyline were required to obtain a therapeutic drug level. (Rifampin label, Drug interactions)

Minor mentions (2)

  • ProbenecidMinor

    The uricosuric action of probenecid is also antagonized by pyrazinamide. (Probenecid label, Drug interactions)

  • Probenecid and colchicineMinor

    The uricosuric action of probenecid is also antagonized by pyrazinamide. (Probenecid and colchicine label, Drug interactions)

Check Pyrazinamide against everything you take. Add your full list; every pair is checked at once.

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.