Interaction Checker

Sepiapterin interactions

Sepiapterin (Sephience) has 15 documented interactions across the FDA labels and fact sheets we index: 7 major, 8 moderate, 0 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (7)

  • Folic acid (folate)Vitamin and mineralMajor

    Effects of Other Drugs on SEPHIENCE Avoid concomitant use of drugs known to inhibit folate synthesis dihydrofolate reductase (DHFR) (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, and piritrexim) while taking SEPHIENCE. (Sepiapterin label, Drug interactions)

  • MethotrexateimmunosuppressantMajor

    Dihydrofolate Reductase (DHFR) Inhibitors : Avoid concomitant use (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, or piritrexim). (Sepiapterin label, Drug interactions)

  • PemetrexedantimetaboliteMajor

    Dihydrofolate Reductase (DHFR) Inhibitors : Avoid concomitant use (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, or piritrexim). (Sepiapterin label, Drug interactions)

  • PralatrexateantimetaboliteMajor

    Dihydrofolate Reductase (DHFR) Inhibitors : Avoid concomitant use (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, or piritrexim). (Sepiapterin label, Drug interactions)

  • Sulfamethoxazole and trimethoprimsulfonamideMajor

    Dihydrofolate Reductase (DHFR) Inhibitors : Avoid concomitant use (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, or piritrexim). (Sepiapterin label, Drug interactions)

  • SulfasalazinesulfonamideMajor

    Sepiapterin Reductase (SR) Inhibitors : Avoid concomitant use (e.g. sulfasalazine or sulfamethoxazole). (Sepiapterin label, Drug interactions)

  • TrimethoprimantibioticMajor

    Dihydrofolate Reductase (DHFR) Inhibitors : Avoid concomitant use (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, or piritrexim). (Sepiapterin label, Drug interactions)

Moderate interactions (8)

  • AmantadineanticholinergicModerate

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (Sepiapterin label, Warnings and precautions)

  • AvanafilPDE5 inhibitorModerate

    Drugs Affecting Nitric Oxide-Mediated Vasorelaxation : Potential for vasorelaxation; monitor blood pressure (e.g., PDE-5 inhibitors). (Sepiapterin label, Drug interactions)

  • Carbidopa and levodopadopaminergic drugModerate

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (Sepiapterin label, Warnings and precautions)

  • Carbidopa, levodopa, and entacaponedopaminergic drugModerate

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (Sepiapterin label, Warnings and precautions)

  • Levodopadopaminergic drugModerate

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (Sepiapterin label, Warnings and precautions)

  • SildenafilPDE5 inhibitorModerate

    Drugs Affecting Nitric Oxide-Mediated Vasorelaxation : Potential for vasorelaxation; monitor blood pressure (e.g., PDE-5 inhibitors). (Sepiapterin label, Drug interactions)

  • TadalafilPDE5 inhibitorModerate

    Drugs Affecting Nitric Oxide-Mediated Vasorelaxation : Potential for vasorelaxation; monitor blood pressure (e.g., PDE-5 inhibitors). (Sepiapterin label, Drug interactions)

  • VardenafilPDE5 inhibitorModerate

    Drugs Affecting Nitric Oxide-Mediated Vasorelaxation : Potential for vasorelaxation; monitor blood pressure (e.g., PDE-5 inhibitors). (Sepiapterin label, Drug interactions)

Check Sepiapterin against everything you take. Add your full list; every pair is checked at once.

Open in the checker

Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.