Sulfadiazine interactions

Sulfadiazine, a sulfonamide has 123 documented interactions across the FDA labels and fact sheets we index: 29 major, 52 moderate, 42 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (29)

  • CONTRAINDICATIONS Atenolol and chlorthalidone is contraindicated in patients with: sinus bradycardia; heart block greater than first degree; cardiogenic shock; overt cardiac failure (See WARNINGS ); anuria; hypersensitivity to this product or to sulfonamide-derived drugs. (Atenolol and chlorthalidone label, Contraindications)

  • Lotensin HCT is also contraindicated in patients who are hypersensitive to benazepril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs. (Benazepril and hydrochlorothiazide label, Contraindications)

  • CONTRAINDICATIONS Bisoprolol fumarate and hydrochlorothiazide tablets are contraindicated in patients in cardiogenic shock, overt cardiac failure (see WARNINGS ), second or third degree AV block, marked sinus bradycardia, anuria, and hypersensitivity to either component of this product or to other sulfonamide-derived drugs. (Bisoprolol and hydrochlorothiazide label, Contraindications)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Major

    CONTRAINDICATIONS Candesartan cilexetil and hydrochlorothiazide tablets are contraindicated in patients who are hypersensitive to candesartan, to hydrochlorothiazide or to other sulfonamide-derived drugs. (Candesartan and hydrochlorothiazide label, Contraindications)

  • CelecoxibNSAIDMajor

    • In patients who have demonstrated allergic-type reactions to sulfonamides [ see Warnings and Precautions (5.7) ]. (Celecoxib label, Contraindications)

  • Chloroprocainelocal anestheticMajor

    Therefore, chloroprocaine should not be used in any condition in which a sulfonamide drug is being employed. (Chloroprocaine label, Precautions)

  • Chlorothiazidethiazide diureticMajor

    Hypersensitivity to this product or to other sulfonamide-derived drugs. (Chlorothiazide label, Contraindications)

  • Chlorthalidonethiazide diureticMajor

    THALITONE is contraindicated in patients with anuria or hypersensitivity to chlorthalidone or other sulfonamide-derived drugs. (Chlorthalidone label, Contraindications)

  • CidofovirantiviralMajor

    Cidofovir injection is contraindicated in patients with a history of clinically severe hypersensitivity to probenecid or other sulfa-containing medications. (Cidofovir label, Contraindications)

  • Dichlorphenamidecarbonic anhydrase inhibitorMajor

    KEVEYIS is contraindicated in the following circumstances: Hypersensitivity to dichlorphenamide or other sulfonamides [see Warnings and Precautions (5.1) ] Concomitant use of KEVEYIS and high dose aspirin [see Warnings and Precautions (5.2) and Drug Interactions (7.1) ] Severe pulmonary disease, limiting compensation to metabolic acidosis caused by KEVEYIS [see… (Dichlorphenamide label, Contraindications)

  • Dutasteride and tamsulosin5-alpha reductase inhibitorMajor

    If a patient reports a serious or life-threatening sulfa allergy, caution is warranted when administering tamsulosin-containing products, including JALYN. (Dutasteride and tamsulosin label, Warnings and precautions)

  • Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (Enalapril and hydrochlorothiazide label, Contraindications)

  • Fosinopril sodium and hydrochlorothiazide is also contraindicated in patients who are hypersensitive to fosinopril, to any other ACE inhibitor, to hydrochlorothiazide, or other sulfonamide-derived drugs, or any other ingredient or component in the formulation. (Fosinopril and hydrochlorothiazide label, Contraindications)

  • GlimepiridesulfonylureaMajor

    • Sulfonamide derivatives: Patients who have developed an allergic reaction to sulfonamide derivatives may develop an allergic reaction to glimepiride tablets.Do not use glimepiride tablets in patients who have a history of an allergic reaction to sulfonamide derivatives. (Glimepiride label, Contraindications)

  • GlipizidesulfonylureaMajor

    • Hypersensitivity to sulfonamide derivatives. ▪ Known hypersensitivity to glipizide or any of the product's ingredients ( 4 ). ▪ Hypersensitivity to sulfonamide derivatives ( 4 ). (Glipizide label, Contraindications)

  • Hydrochlorothiazidethiazide diureticMajor

    In patients with hypersensitivity to sulfonamide-derived drugs. (Hydrochlorothiazide label, Contraindications)

  • Indapamidethiazide diureticMajor

    Known hypersensitivity to indapamide or to other sulfonamide-derived drugs. (Indapamide label, Contraindications)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Major

    Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (Irbesartan and hydrochlorothiazide label, Contraindications)

  • Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (Lisinopril and hydrochlorothiazide label, Contraindications)

  • MecamylamineantihypertensiveMajor

    Patients receiving antibiotics and sulfonamides should generally not be treated with ganglion blockers. (Mecamylamine label, Contraindications)

  • Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide- derived drugs. (Metoprolol and hydrochlorothiazide label, Contraindications)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Major

    Because of the hydrochlorothiazide component, olmesartan medoxomil, amlodipine and hydrochlorothiazide tablet is contraindicated in patients with anuria, hypersensitivity to any component, or hypersensitivity to other sulfonamide-derived drugs. (Olmesartan, amlodipine, and hydrochlorothiazide label, Contraindications)

  • Pioglitazone and glimepiridethiazolidinedioneMajor

    Use in patients with known history of an allergic reaction to sulfonamide derivatives. (Pioglitazone and glimepiride label, Contraindications)

  • PyrimethamineantimalarialMajor

    In infants less than 2 months of age (except as adjunctive therapy with pyrimethamine in the treatment of congenital toxoplasmosis). (Sulfadiazine label, Contraindications)

  • Because of the hydrochlorothiazide components, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (Quinapril and hydrochlorothiazide label, Contraindications)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistMajor

    CONTRAINDICATIONS Spironolactone and hydrochlorothiazide tablets are contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, hypercalcemia, hyperkalemia, Addison's disease, and in patients who are allergic to thiazide diuretics or to other sulfonamide-derived drugs. (Spironolactone and hydrochlorothiazide label, Contraindications)

  • Tamsulosinalpha blockerMajor

    If a patient reports a serious or life-threatening sulfa allergy, caution is warranted when administering tamsulosin hydrochloride capsules. (Tamsulosin label, Warnings and precautions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticMajor

    Hypersensitivity Hypersensitivity to either drug in the preparation or to other sulfonamide-derived drugs is a contraindication. (Triamterene and hydrochlorothiazide label, Contraindications)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Major

    Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. (Valsartan and hydrochlorothiazide label, Contraindications)

Moderate interactions (52)

  • AlmotriptantriptanModerate

    Use with caution in patients with a known hypersensitivity to sulfonamides ( 5.8 ) (Almotriptan label, Warnings and precautions)

  • ApixabananticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • ArgatrobananticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • Articaine and epinephrinelocal anestheticModerate

    …procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Monoamine… (Articaine and epinephrine label, Drug interactions)

  • AspirinNSAIDModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Aspirin and dipyridamoleantiplatelet agentModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • BalsalazidesalicylateModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Bismuth subsalicylatesalicylateModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • BivalirudinanticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • Bromocriptinedopamine agonistModerate

    Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects. (Bromocriptine label, Drug interactions)

  • Bupivacaine and epinephrinelocal anestheticModerate

    …procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine 7.6 Potent… (Bupivacaine and epinephrine label, Drug interactions)

  • Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • DabigatrananticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • DarunavirantiretroviralModerate

    Use with caution in patients with a known sulfonamide allergy. (Darunavir label, Warnings and precautions)

  • Darunavir and cobicistatantiretroviralModerate

    Monitor in patients with a known sulfonamide allergy. (Darunavir and cobicistat label, Warnings and precautions)

  • DiflunisalNSAIDModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • EdoxabananticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • EnoxaparinanticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • FenoprofenNSAIDModerate

    Intervention: Patients receiving hydantoins, sulfonamides, or sulfonylureas should be observed for increased activity of these drugs and, therefore, signs of toxicity from these drugs. (Fenoprofen label, Drug interactions)

  • FondaparinuxanticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • FosamprenavirantiretroviralModerate

    Fosamprenavir calcium should be used with caution in patients with a known sulfonamide allergy. (Fosamprenavir label, Warnings and precautions)

  • FosphenytoinanticonvulsantModerate

    …fluorouracil Antidepressants Fluoxetine, fluvoxamine, sertraline Gastric acid reducing agents H 2 antagonists (cimetidine), omeprazole Sulfonamides Sulfamethizole, sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim Other Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate,… (Fosphenytoin label, Drug interactions)

  • Glipizide and metforminsulfonylureaModerate

    Glipizide: The hypoglycemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta-adrenergic blocking agents. (Glipizide and metformin label, Precautions)

  • GlyburidesulfonylureaModerate

    …Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. (Glyburide label, Drug interactions)

  • HeparinanticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • IndomethacinNSAIDModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Insulin aspartinsulinModerate

    Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. (Insulin aspart label, Drug interactions)

  • Insulin degludecinsulinModerate

    …May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. (Insulin degludec label, Drug interactions)

  • Insulin detemirinsulinModerate

    …May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. (Insulin detemir label, Drug interactions)

  • Insulin glargineinsulinModerate

    …May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, and SGLT-2 inhibitors. (Insulin glargine label, Drug interactions)

  • Insulin lisproinsulinModerate

    Clinically Significant Drug Interactions with LYUMJEV Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. (Insulin lispro label, Drug interactions)

  • …Receptor Blocking Agents, Disopyramide, Fibrates, Fluoxetine, Monoamine Oxidase Inhibitors, Pentoxifylline, Pramlintide, Salicylates, Somatostatin Analogs (e.g., octreotide), and Sulfonamide Antibiotics Prevention or Management Monitor blood glucose more frequently and modify AFREZZA dosage, as clinically indicated, when used concomitantly with these drugs. (Insulin regular (human) label, Drug interactions)

  • Lidocaine and epinephrinelocal anestheticModerate

    …procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine 7.6 Potent… (Lidocaine and epinephrine label, Drug interactions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Losartan and hydrochlorothiazide label, Warnings and precautions)

  • Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Mepivacainelocal anestheticModerate

    …procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine (Mepivacaine label, Drug interactions)

  • MesalaminesalicylateModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • MethotrexateimmunosuppressantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Olmesartan and hydrochlorothiazide label, Warnings and precautions)

  • Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • PhenytoinanticonvulsantModerate

    …fluorouracil Antidepressants Fluoxetine, fluvoxamine, sertraline Gastric acid reducing agents H 2 antagonists (cimetidine), omeprazole Sulfonamides Sulfamethizole, sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim Other Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate,… (Phenytoin label, Drug interactions)

  • Prilocaine and epinephrinelocal anestheticModerate

    …procaine, ropivacaine, tetracaine Antineoplastic Agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine The administration… (Prilocaine and epinephrine label, Drug interactions)

  • ProbenecidModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • RivaroxabananticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

  • Ropivacainelocal anestheticModerate

    …procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine NAROPIN… (Ropivacaine label, Drug interactions)

  • SalsalateNSAIDModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Like other sulfonamide-containing drugs, sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics. (Sulfamethoxazole and trimethoprim label, Drug interactions)

  • SulfasalazinesulfonamideModerate

    Conversely, agents such as indomethacin, probenecid and salicylates may displace sulfonamides from plasma albumin and increase the concentrations of free drug in plasma. (Sulfadiazine label, Drug interactions)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Telmisartan and hydrochlorothiazide label, Warnings and precautions)

  • WarfarinanticoagulantModerate

    Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (Sulfadiazine label, Drug interactions)

Minor mentions (42)

  • AcarboseantidiabeticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Acetazolamidecarbonic anhydrase inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • AlogliptinDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Alogliptin and metforminDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Amiloridepotassium-sparing diureticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Amoxicillinpenicillin antibioticMinor

    Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)

  • Ampicillinpenicillin antibioticMinor

    Bacteriostatic Antibiotics : Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. (Ampicillin label, Drug interactions)

  • BexagliflozinSGLT2 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Bumetanideloop diureticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • CanagliflozinSGLT2 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • DapagliflozinSGLT2 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Dapagliflozin and metforminSGLT2 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • DulaglutideGLP-1 receptor agonistMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • EmpagliflozinSGLT2 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Empagliflozin and metforminSGLT2 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Eplerenonealdosterone antagonistMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Ethacrynic acidloop diureticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • ExenatideGLP-1 receptor agonistMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Furosemideloop diureticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Glyburide and metforminsulfonylureaMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • LinagliptinDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Linagliptin and metforminDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • LiraglutideGLP-1 receptor agonistMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • MetforminbiguanideMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Methylene blueMAO inhibitorMinor

    Lack of Effectiveness Methemoglobinemia may not resolve or may rebound after response to treatment with PROVAYBLUE in patients with methemoglobinemia due to aryl amines such as aniline or sulfa drugs such as dapsone. (Methylene blue label, Warnings and precautions)

  • Metolazonethiazide diureticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • MiglitolantidiabeticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • NateglinidemeglitinideMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Penicillin Gpenicillin antibioticMinor

    Drug Interactions Bacteriostatic antibacterials ( i.e. , chloramphenicol, erythromycins, sulfonamides or tetracyclines) may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. (Penicillin G label, Drug interactions)

  • PioglitazonethiazolidinedioneMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Pioglitazone and metforminthiazolidinedioneMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • RepaglinidemeglitinideMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • SaxagliptinDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Saxagliptin and metforminDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • SemaglutideGLP-1 receptor agonistMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Silver sulfadiazinesulfonamideMinor

    There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides. (Silver sulfadiazine label, Warnings and precautions)

  • SitagliptinDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Sitagliptin and metforminDPP-4 inhibitorMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Spironolactonealdosterone antagonistMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • TirzepatideGLP-1 receptor agonistMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Torsemideloop diureticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

  • Triamterenepotassium-sparing diureticMinor

    Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (Sulfadiazine label, Drug interactions)

Check Sulfadiazine against everything you take. Add your full list; every pair is checked at once.

Open in the checker

Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.