Interaction Checker

Tranexamic acid interactions

Tranexamic acid (Lysteda, Cyklokapron), an antifibrinolytic has 15 documented interactions across the FDA labels and fact sheets we index: 12 major, 0 moderate, 2 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (12)

  • Conjugated estrogensestrogenMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • Drospirenone and ethinyl estradioloral contraceptiveMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • EstradiolestrogenMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • LevonorgestrelprogestinMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • Levonorgestrel and ethinyl estradioloral contraceptiveMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • MedroxyprogesteroneprogestinMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • MegestrolprogestinMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • NorethindroneprogestinMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • Norethindrone and ethinyl estradioloral contraceptiveMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • Norgestimate and ethinyl estradioloral contraceptiveMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • ProgesteroneprogestinMajor

    Concomitant use of combined hormonal contraceptives ( 4.1 ) (Tranexamic acid label, Contraindications)

  • TretinoinretinoidMajor

    Patients with Acute Promyelocytic Leukemia Taking Concomitant All-Trans Retinoic Acid (Oral Tretinoin) Tranexamic acid USP tablets are not recommended in patients with acute promyelocytic leukemia taking all-trans retinoic acid for remission induction because of possible exacerbation of the procoagulant effect of all-trans retinoic acid [see Drug Interactions… (Tranexamic acid label, Warnings and precautions)

Minor mentions (2)

  • ApixabananticoagulantMinor

    There is no experience with antifibrinolytic agents (tranexamic acid, aminocaproic acid) in individuals receiving apixaban. (Apixaban label, Warnings and precautions)

  • Tobacco and smokingTobacco and cannabisMinor

    This is of particular concern in women who are obese or smoke cigarettes, especially smokers over 35 years of age. (Tranexamic acid label, Warnings and precautions)

No significant interaction reported (1)

  • EdoxabananticoagulantNo interaction

    Protamine sulfate, vitamin K, and tranexamic acid are not expected to reverse the anticoagulant activity of SAVAYSA. (Edoxaban label, Warnings and precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.