Interaction Checker

Vericiguat interactions

Vericiguat (Verquvo), a vasodilator has 13 documented interactions across the FDA labels and fact sheets we index: 4 major, 5 moderate, 4 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (4)

  • AvanafilPDE5 inhibitorMajor

    PDE-5 Inhibitors: Concomitant use is not recommended. (Vericiguat label, Drug interactions)

  • SildenafilPDE5 inhibitorMajor

    PDE-5 Inhibitors: Concomitant use is not recommended. (Vericiguat label, Drug interactions)

  • TadalafilPDE5 inhibitorMajor

    PDE-5 Inhibitors: Concomitant use is not recommended. (Vericiguat label, Drug interactions)

  • VardenafilPDE5 inhibitorMajor

    PDE-5 Inhibitors: Concomitant use is not recommended. (Vericiguat label, Drug interactions)

Moderate interactions (5)

  • CaptoprilACE inhibitorModerate

    Valvular Stenosis: There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular risk of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. (Captopril label, Precautions)

  • Dexmedetomidinealpha-adrenergic agonistModerate

    • Co-administration with Other Vasodilators or Negative Chronotropic Agents: Use with caution due to additive pharmacodynamic effects. (Dexmedetomidine label, Warnings and precautions)

  • Isosorbide dinitratenitrateModerate

    Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (Isosorbide dinitrate label, Drug interactions)

  • Isosorbide mononitratenitrateModerate

    The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. (Isosorbide mononitrate label, Drug interactions)

  • Verapamilcalcium channel blockerModerate

    Antihypertensive Agents Verapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers) will usually have an additive effect on lowering blood pressure. (Verapamil label, Drug interactions)

Minor mentions (4)

  • Alfuzosinalpha blockerMinor

    Phosphodiesterase-5 (PDE5) Inhibitors: PDE5-inhibitors are also vasodilators. (Alfuzosin label, Warnings and precautions)

  • Dutasteride and tamsulosin5-alpha reductase inhibitorMinor

    Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (Dutasteride and tamsulosin label, Warnings and precautions)

  • EpinephrinesympathomimeticMinor

    Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants • Monoamine oxidase (MAO) inhibitors • Catechol-O-methyl transferase (COMT)… (Epinephrine label, Drug interactions)

  • Tamsulosinalpha blockerMinor

    Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (Tamsulosin label, Warnings and precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.