Acitretin and Methotrexate interaction
Acitretin and Methotrexate: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Acitretin label · effective 2026-08-05
An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate.
Consequently, the combination of methotrexate with acitretin is also contraindicated (see PRECAUTIONS: Drug Interactions ).
Consequently, the combination of methotrexate with acitretin is also contraindicated (see CONTRAINDICATIONS ).
Methotrexate: An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate.
From the Methotrexate (Xatmep) label · effective 2026-05-28
Monitor patients receiving XATMEP with other potential hepatotoxins (e.g., azathioprine, retinoids, and sulfasalazine) for possible signs of hepatotoxicity.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.