Alcohol and Duloxetine interaction
Alcohol and Duloxetine: the Duloxetine prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Duloxetine label · effective 2026-03-02
Avoid use in patients with substantial alcohol use or evidence of chronic liver disease.
Alcohol Prevention or Management Avoid use in patients with chronic liver disease or heavy alcohol use [see Warnings and Precautions ( 5.2 )] .
Because it is possible that Duloxetine Delayed-Release Capsules and alcohol may interact to cause liver injury or that Duloxetine Delayed-Release Capsules may aggravate pre-existing liver disease, Duloxetine Delayed-Release Capsules should not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease.
Mechanism and Clinical Effect(s) Concomitant use of Duloxetine Delayed-Release Capsules and alcohol may cause liver injury or aggravate pre-existing liver disease.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.