Alcohol and Milnacipran interaction
Alcohol and Milnacipran: the Milnacipran prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Milnacipran (Milnacipran Hydrochloride) label · effective 2026-03-19
Avoid concomitant use of milnacipran hydrochloride in patients with substantial alcohol use or chronic liver disease ( 5.6 ).
Concomitant Use with Alcohol In clinical trials, more patients treated with milnacipran hydrochloride developed elevated transaminases than did placebo treated patients [see Warnings and Precautions ( 5.6 )] .
Milnacipran hydrochloride should ordinarily not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease.
Because it is possible that milnacipran may aggravate pre-existing liver disease, milnacipran hydrochloride should not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.