Alcohol and Nortriptyline interaction

Alcohol and Nortriptyline: the Nortriptyline prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

Curated guidance for Alcohol

Major

Combining alcohol with sedating medicines (opioids, benzodiazepines, sleep medicines, muscle relaxants) can cause dangerous drowsiness, slowed breathing, and overdose.

From the Nortriptyline (PAMELOR) label · effective 2024-12-04

Minor

The patient should be informed that the response to alcohol may be exaggerated.

Drug interactionsnames AlcoholView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.