Alcohol and Posaconazole interaction

Alcohol and Posaconazole: the Posaconazole prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Posaconazole (NOXAFIL) label · effective 2026-02-13

Major

Prevention or Management Administration of Noxafil PowderMix with alcohol is not recommended.

Drug interactionsnames AlcoholView label on DailyMed

Minor

Noxafil Oral PowderMix Alcohol Mechanism and Clinical Effect(s) Posaconazole releases faster from Noxafil PowderMix in the presence of alcohol, which may interfere with Noxafil PowderMix’s delayed-release characteristics [see Clinical Pharmacology (12.3) ].

Drug interactionsnames AlcoholView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.