Alfuzosin and Lofexidine interaction
Alfuzosin and Lofexidine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Alfuzosin (Uroxatral) label · effective 2024-12-05
Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5.1 )
Antihypertensive Medication and Nitrates There may be an increased risk of hypotension/postural hypotension and syncope when taking UROXATRAL concomitantly with anti-hypertensive medication and nitrates [see Warnings and Precautions (5.1) ] .
From the Lofexidine label · effective 2026-07-22
Risk of QT Prolongation : Lofexidine tablets prolong the QT interval.
Risk of QT Prolongation Lofexidine tablets prolong the QT interval.
Methadone : Methadone and Lofexidine tablets both prolong the QT interval.
Methadone Lofexidine tablets and methadone both prolong the QT interval.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.