Allopurinol and Aminophylline interaction
Allopurinol and Aminophylline: the Aminophylline prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Aminophylline label · effective 2026-05-22
30% increase Allopurinol Decreases theophylline clearance at allopurinol doses ≥600 mg/day.
Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.