Alteplase and Perindopril interaction
Alteplase and Perindopril: the Alteplase prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Alteplase (Activase) label · effective 2026-01-20
In the post-marketing setting, there have been reports of angioedema in patients (primarily patients with AIS) receiving concomitant angiotensin-converting enzyme inhibitors. [see Warnings and Precautions (5.2) ].
Concomitant angiotensin-converting enzyme inhibitors may increase the risk of angioedema.
In many cases, patients received concomitant angiotensin-converting enzyme inhibitors [see Drug Interactions (7) ] .
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.