Amantadine and Sulfamethoxazole and trimethoprim interaction
Amantadine and Sulfamethoxazole and trimethoprim: the Sulfamethoxazole and trimethoprim prescribing label mentions this combination without an instruction to avoid it or change the dose.
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Sulfamethoxazole and trimethoprim (SULFATRIM) label · effective 2026-01-05
In the literature, a single case of toxic delirium has been reported after concomitant intake of sulfamethoxazole/trimethoprim and amantadine.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.