Amiloride and Chlorothiazide interaction
Amiloride and Chlorothiazide: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Amiloride (amiloride hydrochloride) label · effective 2023-05-05
Hyperkalemia occurs commonly (about 10%) when amiloride is used without a kaliuretic diuretic.
When amiloride HCl is used concomitantly with a thiazide diuretic in patients without these complications, the risk of hyperkalemia is reduced to about 1-2 percent.
It is thus essential to monitor serum potassium levels carefully in any patient receiving amiloride, particularly when it is first introduced, at the time of diuretic dosage adjustments, and during any illness that could affect renal function.
Diabetes Mellitus In diabetic patients, hyperkalemia has been reported with the use of all potassium-conserving diuretics, including amiloride HCl, even in patients without evidence of diabetic nephropathy.
(See WARNINGS .) Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.
From the Chlorothiazide (DIURIL) label · effective 2021-11-01
Thiazides may add to or potentiate the action of other antihypertensive drugs.
Lithium generally should not be given with diuretics (see PRECAUTIONS , Drug Interactions ).
Other Antihypertensive Drugs - additive effect or potentiation.
Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Including Selective Cyclooxygenase-2 (COX-2) Inhibitors - In some patients, the administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.