Amiodarone and Topotecan interaction
Amiodarone and Topotecan: the Topotecan prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Major
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Topotecan (HYCAMTIN) label · effective 2023-09-18
Major
Avoid concomitant use HYCAMTIN capsules with P-gp inhibitors or BCRP inhibitors.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.