Amlodipine and olmesartan and Atenolol and chlorthalidone interaction
Amlodipine and olmesartan and Atenolol and chlorthalidone: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Amlodipine and olmesartan (AMLODIPINE and OLMESARTAN medoxomil) label · effective 2026-01-03
In patients with an activated renin-angiotensin system, such as volume and/or salt-depleted patients (e.g., those being treated with high doses of diuretics) symptomatic hypotension may be anticipated after initiation of treatment with olmesartan medoxomil .
…Medoxomil Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAID S , including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including olmesartan…
From the Atenolol and chlorthalidone label · effective 2025-09-22
Because of its relative beta 1 -selectivity, however, atenolol and chlorthalidone may be used with caution in patients with bronchospastic disease who do not respond to or cannot tolerate, other antihypertensive treatment.
Drug Interactions Atenolol and chlorthalidone may potentiate the action of other antihypertensive agents used concomitantly.
Calcium channel blockers may also have an additive effect when given with atenolol and chlorthalidone.
Concomitant Use of Calcium Channel Blockers Bradycardia and heart block can occur and the left ventricular end diastolic pressure can rise when beta- blockers are administered with verapamil or diltiazem.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.