Antacids (Tums, Maalox, Mylanta) and Diclofenac and misoprostol interaction
Antacids (Tums, Maalox, Mylanta) and Diclofenac and misoprostol: the Diclofenac and misoprostol prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Diclofenac and misoprostol (Diclofenac sodium and Misoprostol) label · effective 2026-08-31
Intervention: Concomitant use of diclofenac sodium/misoprostol and magnesium-containing antacids is not recommended.
Antacids Clinical Impact: Antacids reduce the bioavailability of misoprostol acid.
Antacids may also delay absorption of diclofenac.
Magnesium-containing antacids exacerbate misoprostol-associated diarrhea.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.