Antacids (Tums, Maalox, Mylanta) and Dicyclomine interaction
Antacids (Tums, Maalox, Mylanta) and Dicyclomine: the Dicyclomine prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Dicyclomine (DICYCLOMINE HYDROCHLORIDE) label · effective 2026-08-12
Effect of Antacids Because antacids may interfere with the absorption of anticholinergic agents including dicyclomine hydrochloride, simultaneous use of these drugs should be avoided.
Antacids: interfere with the absorption of anticholinergic agents (7)
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.