Argatroban and Tirofiban interaction

Argatroban and Tirofiban: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Argatroban label · effective 2026-05-03

Moderate

Concomitant use of argatroban with antiplatelet agents, thrombolytics, and other anticoagulants may increase the risk of bleeding.

Warnings and precautionsby drug classView label on DailyMed

From the Tirofiban (AGGRASTAT) label · effective 2025-01-01

Moderate

Concomitant use of fibrinolytics, anticoagulants and antiplatelet drugs increases the risk of bleeding.

Warnings and precautionsby drug classView label on DailyMed
Moderate

Coadministration of fibrinolytics, anticoagulants and antiplatelet agents, increases the risk of bleeding.

Drug interactionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.