Asenapine and Cariprazine interaction
Asenapine and Cariprazine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Asenapine (SAPHRIS) label · effective 2025-01-31
Orthostatic Hypotension, Syncope, and Other Hemodynamic Effects Atypical antipsychotics cause orthostatic hypotension and syncope.
As with other antipsychotic drugs, SAPHRIS should be used with caution in patients with a history of seizures or with conditions that potentially lower the seizure threshold.
SAPHRIS and other antipsychotic drugs should be used cautiously in patients at risk for aspiration.
From the Cariprazine (Vraylar) label · effective 2025-12-18
VRAYLAR and other antipsychotic drugs should be used cautiously in patients at risk for aspiration.
Seizures Like other antipsychotic drugs, VRAYLAR may cause seizures.
Potential for Cognitive and Motor Impairment VRAYLAR, like other antipsychotics, may cause somnolence and has the potential to impair judgment, thinking, or motor skills.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.