Aspirin and dipyridamole and Ticagrelor interaction

Aspirin and dipyridamole and Ticagrelor: the Ticagrelor prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Ticagrelor (BRILINTA) label · effective 2026-05-07

Major

WARNING: BLEEDING RISK • BRILINTA, like other antiplatelet agents, can cause significant, sometimes fatal bleeding ( 5.1 , 6.1 ).

Boxed warningby drug classView label on DailyMed
Major

• BRILINTA, like other antiplatelet agents, can cause significant, • sometimes fatal bleeding.

Boxed warningby drug classView label on DailyMed
Moderate

In the case of intolerable dyspnea requiring discontinuation of BRILINTA, consider prescribing another antiplatelet agent.

Warnings and precautionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.