Aspirin and Oxaprozin interaction
Aspirin and Oxaprozin: the Oxaprozin prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Oxaprozin label · effective 2025-12-03
SECTION OXAPROZIN CAPSULES is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to oxaprozin or any components of the drug product [see WARNINGS AND PRECAUTIONS (5.7, 5.9)] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs (4)
Exacerbation of Asthma Related to Aspirin Sensitivity: OXAPROZIN CAPSULES is contraindicated in patients with aspirin-sensitive asthma.
Exacerbation of Asthma Related to Aspirin Sensitivity A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs.
Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, OXAPROZIN CAPSULES is contraindicated in patients with this form of aspirin sensitivity [see CONTRAINDICATIONS (4)].
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.