Aspirin and Tadalafil interaction

Aspirin and Tadalafil: the Tadalafil prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Tadalafil (Cialis) label · effective 2026-06-03

Moderate

When administered in combination with aspirin, tadalafil 20 mg did not prolong bleeding time, relative to aspirin alone.

Warnings and precautionsnames AspirinView label on DailyMed
Moderate

Potential for CIALIS to Affect Other Drugs Aspirin — Tadalafil did not potentiate the increase in bleeding time caused by aspirin.

Drug interactionsnames AspirinView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.