Atenolol and Digoxin interaction

Atenolol and Digoxin: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Atenolol (TENORMIN) label · effective 2025-09-18

Moderate

Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers.

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Moderate

Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate.

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Minor

Disopyramide is a Type I antiarrhythmic drug with potent negative inotropic and chronotropic effects.

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From the Digoxin label · effective 2025-04-10

Moderate

Beta-adrenergic Blockers and Calcium Channel Blockers Additive effects on AV node conduction can result in complete heart block.

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Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.