Atorvastatin and Fenofibrate interaction
Atorvastatin and Fenofibrate: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Atorvastatin (Lipitor) label · effective 2024-04-15
Cases of myopathy/rhabdomyolysis have been reported with atorvastatin co-administered with lipid modifying doses (>1 gram/day) of niacin, fibrates, colchicine, and ledipasvir plus sofosbuvir [see Adverse Reactions (6.1) ] .
The risk of myopathy and rhabdomyolysis is increased with concomitant use of fibrates with LIPITOR.
Intervention: Consider if the benefit of using fibrates concomitantly with LIPITOR outweighs the increased risk of myopathy and rhabdomyolysis.
Fibrates (other than Gemfibrozil) Clinical Impact: Fibrates may cause myopathy when given alone.
From the Fenofibrate label · effective 2026-05-12
Risks are increased during co-administration with a statin, in geriatric patients and in patients with renal impairment, or hypothyroidism.
Pemafibrate did not reduce cardiovascular disease morbidity or mortality in a large, randomized, placebo - controlled trial of patients with type 2 diabetes mellitus on background statin therapy [see Clinical Studies (14.4) ].
Steps to Prevent or Reduce the Risk of Myopathy and Rhabdomyolysis Data from observational studies indicate that the risk for rhabdomyolysis is increased when fibrates, including fenofibrates, are co-administered with a statin.
The risk of myopathy and rhabdomyolysis is increased with concomitant use of fibrates with statins.
Intervention: Consider if the benefit of using fenofibrate concomitantly with statin therapy outweighs the increased risk of myopathy and rhabdomyolysis.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.