Atropine and pralidoxime and Donepezil interaction
Atropine and pralidoxime and Donepezil: both prescribing labels mention this combination without an instruction to avoid it or change the dose.
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Atropine and pralidoxime (ATNAA atropine and pralidoxime chloride Auto-Injector) label · effective 2022-07-18
…ATNAA reactivates cholinesterases and succinylcholine and mivacurium are metabolized by cholinesterases, service members poisoned by susceptible organophosphorus nerve agents having anticholinesterase activity who have received ATNAA may exhibit accelerated reversal of the neuromuscular blocking effects of succinylcholine and mivacurium (relative to poisoned service…
From the Donepezil (Aricept) label · effective 2021-12-30
Cholinesterase inhibitors have the potential to interfere with the activity of anticholinergic medications ( 7.1 )
Use with Anticholinergics Because of their mechanism of action, cholinesterase inhibitors have the potential to interfere with the activity of anticholinergic medications.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.